肾移植术后氨甲酰化血红蛋白的动态观察

SEQUENTIAL DETERMINATION OF CARBAMYLATED HEMOGLOBIN IN RENAL GRAFT RECIPIENTS

目的：了解氨甲酰化血红蛋白在肾移植术后肾功能恢复中的作用。方法：采用高效液相色谱法动态检测28例肾移植患者氨甲酰化血红蛋白含量。结果：肾功能稳定组氨甲酰化血红蛋白在本后第24天接近正常，并与第3天的尿素水平相关性最佳，急性排斥组却变化不大。结论：氨甲酰化血红蛋白是反映尿素浓度及作用时间的参数，可作为肾移植术后肾功能恢复的监测指标。

The carbamylated hemoglobin levels in 28 renal graft recipients were sequentially determined using high perfor-mance liquid chromatography. The carbamylated hemoglobin levels began to approach normal concentrations on the 24th day after transplantation in the stable group, and correlated with the urea concentration on the third day after transplantation. However, the hemoglobin levels did not change in the rejection group. The research indicates that carbamylated hemoglobin is a good index of time averaged urea concentrations and may be useful in monitoring kid-ney function after transplantation.