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组织蛋白酶与动脉粥样硬化斑块稳定性 被引量：3

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摘要 动脉粥样硬化斑块的形成受多重因素的影响,有多种细胞外蛋白酶参与,新近发现组织蛋白酶参与动脉粥样硬化的发展,对斑块稳定性起重要作用。研究组织蛋白酶在人类的生理作用意义重大,可能有助于揭示动脉粥样硬化斑块稳定性的机制,并可为防治急性冠状动脉综合症提供新的方案。
作者 秦彦文 王绿娅
机构地区 首都医科大学附属北京安贞医院动脉粥样硬化研究室
出处 《中国动脉硬化杂志》 CAS CSCD 2007年第12期950-952,共3页 Chinese Journal of Arteriosclerosis
基金 北京市自然科学基金(7082020) 北京市科委重大项目(D0906006040191) 北京市优秀人才培养基金(20071D0300600084)
关键词 内科学 动脉粥样硬化 组织蛋白酶
分类号 R5 [医药卫生—内科学]
  • 相关文献

参考文献32

  • 1Rodgers KJ,Watkins DJ,Miller AL.Chan PY,Sharada K,Brissette WH,et al.Destalbilizing role of cathepsin S in murine atherosclerotic plaques [J].Arterioscler Thromb Vasc Biol, 2006, 26 (4):851-856.
  • 2Papaspyridonos M, Smith A, Burnmand KG, Peter T, Soundrie P, Suckling KE, et al. Novel candidate genes in unstable areas of human atherosclerotic plaques [J]. Arterioscler Thromb Vasc Biol, 2006, 26:1 837.
  • 3郭爱桃,石怀银,韦立新,孙璐.人冠状动脉粥样硬化斑块内细胞成分与斑块稳定性的关系[J].第四军医大学学报,2005,26(22):2093-2096. 被引量：11
  • 4Sofia J, Wuttge DM, Allan S, Carl Whatling, Anders Hamsten, Sten Stemme, et al. Differential expression of cysteine and aspartic proteases during progression of atherosclerosis in apolipoprotein E-deficient mice[J]. Am J Pathol, 2002, 161:939-945.
  • 5Newby AC. Dual role matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture[J]. Physiol Rev, 2005, 85: 1-31.
  • 6吴艳,王毅,杨刚毅.组织蛋白酶K与骨质疏松的研究进展[J].中国骨质疏松杂志,2006,12(5):522-524. 被引量：4
  • 7Chang1 WSW, Wu HR, Yeh CT, Wu CW, Chang JY. Lysosomal cysteine proteinase cathepsin s as a potential target for anti-cancer therapy [ J ]. J Cancer Mol, 2007, 3 (1): 5-14.
  • 8Yoshifuji H, Umehara H, Maruyama H, 1toh M, Tanaka M, Kawabata D, et al. Amelioration of experimental arthritis by a calpain-inhibitory compound:regulation of cytokine production by E-64-d in vivo and in vitro [ J ]. Int Immunol, 2005, 17 (10): 1 327-336.
  • 9Liu J, Sukhova GK. Sun JS, Xu WH, Libby P, Shi GP.Lysosomal cysteine proteases in atherosclerosis[J]. Arterioscler Thromb Vasc Biol, 2004, 24: 1 359-366.
  • 10Sukhova GK, Shi GP. Do cathepsins play a role in abdaminal aortic aneurysm pathogenesis [J]? Ann NY Acad Sci, 2006, 1085: 161-169.

二级参考文献11

  • 1JUNYANG,GUANG-DONGSHANG,YUE-QINZHANG.Study of a Novel Antiosteoporosis Screening Model Targeted on Cathepsin K[J].Biomedical and Environmental Sciences,2004,17(3):273-280. 被引量：12
  • 2Boyle JJ. Macrophage activation in atherosclerosis: Pathogenesis and pharmacology of plaque rupture [J]. Curr Vasc Pharmacol, 2005;3(1):63-74.
  • 3Hennerici MG. The unstable plaque [J]. Cerebrovasc Dis, 2004;17(Suppl 3):17-31.
  • 4Shah PK. Mechanism of plaque vulnerability and rupture [J]. J Am Coll Cardiol, 2003; 41(4 suppl S): S15-S22.
  • 5Kavurma MM, Bhindi R, Lowe HC, et al. Vessel wall apoptosis and atherosclerotic plaque instability [J]. J Thromb Haemost, 2005; 3(3): 465-479.
  • 6Johnson Ad, Berberian PA, Tytell M. Differential distribution of 70-kd heat shock protein in atherosclerosis. Its potential role in arterial SMC survival [J]. Arterioscler Thromb Vasc Biol, 1995; 15(1): 27-36.
  • 7Lee RT, Libby P. The unstable atheroma [J]. Arterioscler Thromb Vasc Biol, 1997; 17: 1859-1867.
  • 8Lindstedt KA, Kovanen PT. Mast cells in vulnerable coronary plaques: potential mechanisms linking mast cell activation to plaque erosion and rupture [J]. Curr Opin Lipidol, 2004;15(5): 567-573.
  • 9韦立新,石怀银,郭爱桃,李向红,游联璧,陈乐真.稳定性、不稳定性心绞痛及急性心肌梗死病人冠状动脉病变的形态学差异[J].中华病理学杂志,1998,27(3):168-170. 被引量：23
  • 10石怀银,韦立新,佘铭鹏,李向红,郭爱桃,游联璧.冠状动脉斑块中炎性细胞和平滑肌细胞的定量及其与斑块稳定性的关系[J].中华病理学杂志,1999,28(4):256-259. 被引量：24

共引文献13

同被引文献30

  • 1刘红梅,黄体钢,王林,甄琴,杨万松.阿司匹林和氟伐他汀对血管紧张素Ⅱ诱导的血管平滑肌细胞环氧合酶2表达的抑制作用[J].中国动脉硬化杂志,2007,15(3):193-196. 被引量：3
  • 2Burns-Kurtis CL, Olzinski AR, Needle S, et al. Cathepsin S expression is up-regulated following balloon angioplasty in the hypercholesterolemic rabbit [J]. Cardiovase Res, 2004, 62 (3) : 610-620.
  • 3Cheng XW, Kuzuya M, Sasaki T, et al. Increased expression of elastolytic cysteine proteases, cathepsins S and K, in the neointirna of balloon-injured rat carotid arteries [J]. Ant J Pathol, 2004, 164 ( 1 ) : 243-251.
  • 4Pang M, Martinez AF, Jacobs J. RANK ligand and interferon gamma differentially regulate cathepsin gene expression in pre-osteoclastic cells [J]. Biochem Biophys Res Commute, 2005, 328 (3) : 756-763.
  • 5Chandrasekar B, Mummidi S, Mahimainatham L, et al. Interleukin-18-induced human coronary artery smooth muscle cell migration is dependent on NF-kappaB- and AP-1-mediated matrix metalloproteinase-9 expression and is inhibited by atorvastatin [J]. J Biol Cbem, 2006, 281 (22) : 15 099-109.
  • 6McDermott, Luke AJ, O'Neill. Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1 [J]. J Biol Chem, 2002, 277 (10) : 7 808-815.
  • 7Ortego M, Gomez-Hemandez A, Vidal C, et al. HMG-CoA reductase inhibitors reduce 1 kappa B kinase activity induced by oxidatiw, strauss in monocytes and vascular smooth muscle cells [ J ]. J Cardiovasc Pharmacol, 2005, 45 (5) : 468-475.
  • 8Holschermann H, Schuster D, Parviz B, et al. Statins prevent NF kappaB transactivation independently of the IKK-pathway in human endothelial cells [J]. Atherosclerosis, 2006, 185 (2): 240-245.
  • 9Lin R, Liu J, Peng N, et al. Lovastatin reduces nuclear factor-κB activation induced by c-reactive protein in human vascular endothelial cells [J]. Biol Pharm Bull, 2005, 28 (9) : 1 630-634.
  • 10Shogo Katsuda, Toshiyuki Kaji. Atherceclerosis and extracellular matrix [ J]. J Atheroscler Thromb , 2003, 10 (5): 267-274.

引证文献3

二级引证文献4

中国动脉硬化杂志
2007年 第12期

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