非洛地平缓释片和氢氯噻嗪双盲5年随访

Prospective follow up for five years' study to plendil and Hydrochlorthiazide treatment of hypertensions

目的观察非洛地平缓释片及氢氯噻嗪双盲对照5年随访对高血压疗效及心脑血管事件发生比较。方法按中国医科院阜外医院Fever研究规划,严格选择50～70岁的高血压病人,入选病人采用多中心双盲非洛地平缓释片2.5～5mg/日,经5年随访,治疗前后测坐位、立位血压、心率;空腹血糖、TC、TG、HOL-CH、OX-LDL、肌酐、尿酸、血钾、心电图等检查并记录心肌梗死、脑猝中的发生。结果67例中非洛地平缓释片组简称T组35例,氯噻嗪对照组C组32例,严格编号入双盲,5年随访结束,由医科院开盲统计。两组基础收缩压、BMIP均>0.01有可比性,治疗前T组收缩压(157.89±9.90)、舒张压(95.26±2.57)治疗后降到(132.03±8.87)及(81.88±4.94)mmHg自身前后对照P<0.01有显著降压作用,但和C组比P>0.05无组间差别,OX-LDL、TC及TG,T组治疗前(98.34±61.4)、(5.45±0.60)、(2.55±0.88),治疗后降到(67.54±36.11)、(4.78±1.06)、(1.92±0.51),自身前后及组间P均为<0.01及<0.05有显著性,C组5年随访中发现心梗塞死1例、脑梗塞1例。结论非洛地平缓释片及小剂量氢氯噻嗪对高血压5年前瞻性研究均有良好降压作用,非洛地平缓释片对TC、TG。

Objective Prospective follow up for five years＇ study to plendil and Hydrochlorthiazide treatment of hypertensions efficecy and sefety follow five years. Methods 67 hypotension patients were divided into trement group with35 patients taking plendil 2.5-5mg/day, control group （c group ） with 32 patients taking Hydrochlorthiazide 12. 5-25mg/day. Respectively five years. These was no difference in age,sex,BMI and systolic blood pressure between the two groups. Before and after treatment examined with E,C,G. Blood pressure and fast intake blood glucose serum Lipid （TC,TG, HDL-C） renal function, serum potassion inspect in all patients and OX-LOL in partials were recorded on determined. Results Blood pressure of two groups after treatment decread （P〈0.01） , T group TC,TG,OX-LDL also decreased （P〈0.01） . The death of two groups were all found during the follow up period at C group （one with acute coronary dyndrome, one with cerebrovascular accident ）Conclusions Conclusion Felodipine sustained-release tablets and small dose of hydrochlorothiazide on the five-year prospective study of hypertension have good lowering effect on TC, TG and OX-LDL.