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PECAM-1基因分子变异与冠心病的相关性

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摘要 目的研究血小板内皮细胞黏附分子-1(PECAM-1)基因分子变异与冠心病的关联。方法选择72例冠心病患者及年龄、性别相匹配的80例正常对照,用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法检测其PECAM-1基因型。比较两组基因型及等位基因频率分布。结果冠心病组V/V基因型频率(40.3%)明显高于对照组(22.5%)(P<0.05);与对照组相比,冠心病组V等位基因频率(59.0%)明显升高(P<0.05),L等位基因频率(40.9%)明显降低(P<0.05);吸烟使V/V基因型者冠心病发病危险度由2.3上升至3.8(P<0.05)。结论PECAM-1基因变异与冠心病相关,V/V基因型可能是本地区人群冠心病的遗传易患因子。
作者 许英 施耀岳
机构地区 江苏省海门市人民医院心内科 江苏省海门市人民医院小儿内科
出处 《齐齐哈尔医学院学报》 2007年第22期2712-2714,共3页 Journal of Qiqihar Medical University
关键词 血小板内皮细胞黏附分子—1基因 聚合酶链反应 冠状动脉疾病
分类号 R587.1 [医药卫生—内分泌] R541.4 [医药卫生—心血管疾病]
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参考文献5

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二级参考文献30

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共引文献9

齐齐哈尔医学院学报
2007年 第22期

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