偏头痛患者血浆P物质与神经激肽A的变化

Level of plasma substance P and neurokinin A in migraine patients without aura

为了探讨偏头痛与Ｐ物质（ＳＰ）、神经激肽Ａ（ＮＫＡ）含量之间的关系，本研究应用放射免疫法测定了６９例无先兆性偏头痛患者组与３１例正常对照组血浆ＳＰ与ＮＫＡ含量，结果发现ＳＰ与ＮＫＡ在偏头痛患者组较正常对照组升高，且偏头痛发作期该两种神经肽较间歇期更高。提示ＳＰ与ＮＫＡ可能通过降低痛阈等机理参予偏头痛的发作。本组男女患者间ＳＰ与ＮＫＡ含量无明显差异，而临床上偏头痛多见于女性，常于月经期发病，提示ＳＰ、ＮＫＡ等虽参予其发病，但性激素变化在男女发病率不同方面可能起较重要作用。

In order to investigate the relationship between substance P, neurokinin A ad migraine, the concentrations of plasma SP and NKA in 69 cases of migraine patients without aura and 31 cases of normal controls were detected by radioimmunoassy. The magraine patients showed a significant increase in SP and NKA levels when compared with the values obtained in controls. And during magraine attack the levels of the two neuropeptides were more higher than that during the remission period. Our data suggested that SP and NKA may decrease the pain threshold involved in the pathogenesis of magraine.The levels of SP or NKA between male and female were of no significantly different, but clinicaly, female migraineurs were more thsn the male, and a lot of female migraine sufferers were associated with the menstrual cycle. It suggest that although SP and NKA may play a role in the pathogenisis of magiaine, but the ovarian hormone may be more important to the different frequency between male and female.