不同途径IL-8测定预测不良妊娠结局的比较研究

Comparative study on interleukin-8 by different ways and forecast of adverse pregnancy outcomes

目的探讨白细胞介素8(interleukin-8,IL-8)对不良妊娠结局预测价值。方法采用酶联免疫吸附(ELISA)法,检测102例异常妊娠孕妇(观察组)及63例同期正常孕妇(对照组)阴道分泌物及血清IL-8含量,同时两组孕妇均取胎膜行病理检查。结果异常妊娠组IL-8含量、绒毛膜羊膜炎发生率明显高于对照组,差异有显著意义(P<0·01、P<0·05)。绒毛膜羊膜炎孕妇IL-8均高于非绒毛膜羊膜炎,差异有显著意义(P<0·01、P<0·05),结论孕妇IL-8变化与不良妊娠结局的关系密切,IL-8可能参与了不良妊娠结局的发生发展,它可作为预测不良妊娠结局和判断绒毛膜羊膜炎的参考指标,并且血清IL-8的有较高敏感性和特异性。

Objective ： To study predictive value of interleukin - 8 （ IL - 8） on adverse pregnancy outcome. Methods. Vaginal secretions and serum IL- 8 levels by enzymelinked immunosorbent assay （ELISA） were detected in 102 cases of abnormal pregnant women （observation group） and 63 patients with normal pregnant women the same period （control group）, while all pregnant women＇ s membranes were examined pathologically. Results： IL- 8 levels, Chorioamnionitis in abnormal pregnancy were significantly higher than control, the difference was significant （ P 〈 0. 01, P 〈 0. 05 ） . IL - 8 levels in Chorioamnionitis pregnant women was higher than non - Chorioamnionitis, the difference was significant （ P 〈 0. 01, P 〈 0. 05） . Conclusion ： IL - 8 changes of pregnant women are closely connected with adverse pregnancy outcomes and IL -8 may be involved in the adverse Pregnancy Outcome in the development, it can be used as prediction of adverse pregnancy outcome and reference indicator of judgment Chorioamnionitis, and serum IL - 8 is a higher sensitivity and specificity.