CT扫描在X刀治疗鼠脑胶质瘤中的应用研究

CT Scan Used in the Study of X Knife Treatment of Rat Glioma

目的：探讨ＣＴ检查在Ｘ刀治疗大鼠Ｃ６胶质瘤中的作用。材料和方法：ＣＴ２ｍｍ薄层扫描，Ｘ刀治疗剂量参照临床患者常用量，定为１５、２０、３０、４０Ｇｙ。经ＣＴ检查，选出适于Ｘ刀５ｍｍ准直器治疗直径的３～５ｍｍ瘤的大鼠４６只，分为治疗和对照组。结果：治疗组大鼠平均生存期４０．４ｄ，对照组２３．５ｄ，两组间有显著差异。ＣＴ复查发现Ｘ刀治疗后大鼠脑肿瘤有所缩小或消失。结论：ＣＴ检查是研究大鼠脑肿瘤的理想方法。

Purpose: Stercotactic radiosurgery (SRS) offers a new option in treating glioma. The understanding for its effectiveness remains to be determined. We firstly try to use enhancement CT examination to confirm the onset of at brain tumor and it's response to SRS, and then to evaluate the role of X knife treatment of rat C6 glioma. Materials and methods: We used rat C6 glioma model via transplantation of the tumor cells to S.D. rat brain. 61 rats were performed CT scan 12 25 days after implantation of tumor cells. 46 rats bearing 3 5 mm diameter tumors were selected for grouping treatment by 5 mm collimator of X knife. The control dose varied from 15, 20, 30 to 40 Gy, corresponding to clinical treatment dose. Results: 61 of 87 implanted animals occurred tumors. The inductive rate is 70.1%. The induced tumor reached to 2～6 mm (mean 3.51.1 mm) diameter at 12～18 days after transplantation and 3～7 mm (mean 5.11.5 mm) at 19～25 days. The treated animals had a mean survival of 40.4 days, while the control animals lived a mean of 23.5 days from tumor growth (P<0.05). The result of CT scan of treated rats showed tumor disappearance in two 15 Gy group animals, but instead of edema, and finally these two rats died identically to the animals of the other dose groups. Conclusion: CT scan is an ideal method in studying the rat brain tumors. X knife treatment can prolong the survival time and can reduce the tumor size of the bearing tumor animals.