肝脏CT值与动脉粥样硬化关系

Relationship of the Value of CT Liver and Atherosclerosis

目的探讨肝脏CT值与动脉粥样硬化(AS)程度的关系,寻找AS活体量化观测指标,提高AS干预实验的质量。方法4O只日本大耳白兔随机分为A(绞股蓝)组、B(辛伐他汀)组、C(高脂模型)组、E(对照组)组,分别喂饲高脂饲料+绞股蓝5 g/kg、高脂饲料+辛伐他汀5 mg/kg、高脂饲料、标准饲料。实验前和实验后3周、6周、9周检测三酰甘油(TG)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)。第7周和第9周进行CT检查。进行动脉和肝脏病理学检测。结果①TG、TC、LDL-C、HDL-C:A组、B组、C组饲养后TG、TC、LDL-C明显升高(P<0.05),A组和B组TG、TC、LDL-C低于C组(P<0.05),A组TG、HDL-C、LDL-C优于B组(P<0.05)。②CT检查:饲养后7周、9周,A、B、C组CT值明显下降,比较有显著性差异(P<0.05),A组高于B组、C组(P<0.01),B组高于C组(P<0.01)。③主动脉病理学:C组严重的大面积AS,A组和B组AS面积和程度显著低于C组(P<0.01)。④肝脏病理学:A组、B组、C组肝脏弥漫性肿大,边缘钝而厚,灰黄色,A组较B组、C组肝脏色泽红润、肿大程度轻。A组2/3以上肝细胞发生脂肪样变。B、C组肝脏脂肪样变几乎为100%。结论肝脏CT值与AS的程度有一定的关系,可作为AS程度的量化指标,对指导实验过程有一定的价值。

Objective To observe liver CT value and atherosclerosis degree relations, is the medicine intervented atherosclerosis tests seeked the nonlethal observation target, Enhances the atherosclerosis to the quality of intervene experimental. Methods 40 rabbits were divided as group A （Fiveleaf Gynostemma Herb）, group B （Simvastain）, group C （high blood fat model）, group E（normal-controlled）at random, which was fed high fat food added Fiveleaf Gynostemma Herb 5 g/kg, high fat feedstuff added simvastain 5 mg/kg, high fat feedstuff and standard feedstuff respectively. TG, TC, LDL-C and HDL-C were checked before the experiment and after the sixth and ninth week of the experiment. Seventh week and the ninth week, the rabbit was inspected on the CT. pathology shape of the liver and the Aortic pathology was observed. Results ① TG, TC, LDL-C and HDL-C： TG,TC and LDL-C of group A, group B and group C were growing gradually. TG,TC,LDL-C of group A and group B were lower than group C （ P 〈 0.05 ）, TG,HDL-C ,LDL-C of group A were better than group B（ P 〈 0.05）.② CT examination： CT values of group A, group B and group C were reducing gradually. Raises seventh week, nineth week, group A of CT value is higher than B group, C group（ P 〈 0.01 ）, group B of CT value is higher than group C（ P 〈 0.01 ）. ③ Aortic pathology： A group of and B group of AS area and the degree remarkably are lower than C group （ P 〈 0.01 ）. ④ examined by liver pathology： the livers of group A, group B and group C were diffuse swellings, the fringe was blunt and thick with the color of grey yellow. Compared with group B and C, the liver of group A was flush ruddy and the degree of liver swelling was lightened. 2/3 of the hepatocyte of group A had the change of fatty and become the moderate fatty liver. The happened rate of fatty liver was 100%. Conclusion The liver CT value and the liver fatty type changes the degree, the atherosclerosis degree has the certain relations, may test the atherosclerosis degree indirect target as the medicine atherosclerosis, to instructs the experimental process to have the certain value.