兔眼滤过性手术中植入硅凝胶膜的实验研究(英文)

Experimental study of silicone membrane implanted beneath the scleral flap during filtering surgery in rabbits

目的:在兔眼行硅凝胶膜植入后,通过观察眼内压、滤过泡、病理组织检查结果评价硅凝胶膜植入的安全性和有效性。方法:共40只兔随机分为4组,每组10只。每只兔一眼行巩膜瓣下小梁咬切术,术中植入硅凝胶膜,对侧眼单纯行巩膜瓣下小梁咬切术作为对照。术后观察眼内压、滤过泡的变化,并且每只眼行组织病理学检查。结果:植入眼较对照眼低眼压和滤过泡维持时间长,光镜显示植入眼滤过道、咬切口区保持通畅。成纤维细胞增殖的活性与规律,在植入眼和对照眼是相似的。硅凝胶膜不会刺激成纤维细胞增殖的过度表达。结论:硅凝胶膜植入术作为一种新型引流术具有安全、有效、操作简单的优点。

AIM： To investigate the efficacy and security of the silicone membrane implant through observing intraocular pressure, filtering blebs and histopathologic results. METHODS：Forty rabbits were randomly divided into 4 groups. Each group consisted of 10 rabbits. Trabeculectomy and silicone membrane implantation were performed in one eye of each rabbit, while the other eye was only performed trabeculectomy as control. The change of intraocular pressure, filtering blebs were observed postoperatively. And each eye had undergone histopathologic examination. RESULTS：The duration of low intraocular pressure and existence of filtering blebs in implanted eyes was longer than that in controlled eyes. Light microscopy revealed that patent drainage tract and biting site could be seen in silicone membrane implanted eye. The activity and regularity of fibroblast proliferation in implanted eyes and controlled eyes were similar. Excessive expression of fibroblast proliferation was not induced by silicone membrane. CONCLUSION： Characterized by safety, effectiveness and simplicity, silicone membrane implantation can act as a new drainage surgery.