准分子激光原位角膜磨镶术对托吡卡胺角膜渗透性的影响

Effect of laser in situ keratomileusis on corneal penetration of tropicamide

目的:探讨准分子激光原位角膜磨镶术(laser in situkera-tomileusis,LASIK)对托吡卡胺角膜渗透性的影响。方法:对34例(64眼)接受LASIK治疗的近视眼患者,于术前和术后1mo测量并比较10g/L托吡卡胺扩瞳后5,10,15,20min以及25min时的瞳孔大小,并记录瞳孔达到6mm大小所需时间。结果:平均中央角膜厚度由术前555.4±32.3μm下降至术后475.6±33.5μm,差异有显著意义。术后1mo10g/L托吡卡胺扩瞳后10,15,20min时的瞳孔直径明显大于术前相应时间点的瞳孔大小,而5,25min时的瞳孔大小无显著性差别。瞳孔达到6mm大小所需平均时间由术前14.66±4.28min减少至12.42±2.16min。结论:LASIK术后托吡卡胺的扩瞳作用显著加快。LASIK导致的角膜变薄增强了托吡卡胺的角膜渗透性。

AIM： To investigate the effect of laser in situ keratomileusis （ LASIK ） on the corneal penetration of tropicamide. METHODS： LASIK was performed in 64 eyes of 34 patients. After instillation of tropicamide 10g/L, pupil size at different time points was measured and the time to reach a pupil diameter of 6mm was recorded before surgery and at 1 month after surgery. RESULTS： The mean central corneal thickness （CCT） decreased from 555.4 ± 32.31J m before LASIK to 475.6 ± 33.5lure at 1 month postoperatively. Pupil diameter at 10, 15, and 20 minutes after tropicamide 10g/L instillation was significantly larger 1 month after surgery than preoperatively. The mean time to reach a pupil size of 6mm decreased significantly from 14, 66 ± 4. 28 minutes in preoperative eyes to 12.42 ± 2.16 minutes in postoperative eyes, CONCLUSION： Pupil dilation after tropicamide 10g/L instillation is significantly faster after LASIK surgery. Corneal thinning resulted from LASIK enhances corneal penetration of tropicamide.