社区居民乙肝病毒感染情况分析

Analysis on Hepatitis B Virus Infection Condition of Citizens in Shaoxing

目的掌握成人乙型肝炎病毒(HBV)感染情况,为制定成人乙肝疫苗免疫策略提供依据。方法在绍兴市某城区随机抽取18～50岁的职工1309名,抽取静脉血进行乙肝表面抗原(HBsAg)、表面抗体(抗-HBs)、核心抗体(抗-HBc)检测。结果检测人群1236名,检测率94.42%,HBsAg阳性率7.61%,男女各为9.92%、4.53%,不同性别、年龄人群的HBsAg阳性率有显著差异(χ2=12.49,P<0.01)。抗-HBs阳性率为48.38%,男女阳性率分别为46.60%、50.75%;抗-HBc阳性率53.12%%,不同年龄、性别的抗-HBs、抗-HBc水平经统计学处理基本一致。人群HBV3项指标感染率72.01%,不同年龄组间的感染率有显著差异(χ2=8.05,P<0.05)。结论我市人群HBV感染率处于较高水平,提示成人是乙肝防治的重点人群,应尽快制定成人乙肝疫苗免疫方案,以建立有效的全人群防御乙肝的免疫屏障,达到加速控制乙肝进程的目的。

Objective Analyze hepatitis B virus （HBV） infection condition in adults, and provide scientific basis for building immune effects of HB vaccine in adults. Methods In Shaoxing city, randomly select 1309 adults between the age of 18 and 50, draw their venous blood and test HBsAg, anti - HBs and anti - HBc. Results 1236 adults completed the test and the testing rate was 94.42%. The positive rate of HBsAg was 7.61% , 9.92% in men and 4.53% in women. Positive rates of HBsAg of different genders and ages showed significant difference （Х^2 = 12.49, P 〈 0.01 ）. The positive rate of anti - HBs was 48.38% , 46.60% in men and 50.75% in women. Anti - HBc positive rate was 53.12% %. Anti - HBs and anti - HBc levels of different ages and genders, according to statistical analysis, were on the whole identical. The infection rate of HBV three indexes was 72.01% , with a significant difference （Х^2 = 8.05, P 〈 0.05 ） among people of different ages. Conclusions The infection rate of HBV among people in Shaoxing is pretty high, suggesting that adults are the focal point against HBV infection. Our society should strengthen HBV immunization for adults, build effective immune barrier among people, and finally advance the control over Hepatitis B.