腔隙性脑梗死患者工作记忆障碍研究

The Study on Working Memory Impairment in Patients with Lacunar Cerebral Infarctions

目的探讨腔隙性脑梗死(LCI)患者工作记忆障碍特点。方法选择42名经临床证实的LCI患者,分为多灶LCI组与单灶LCI组、以及左侧、右侧与双侧梗死组,分别进行数字排序测验、Corsi模板任务、房子视觉广度测验和Stroop数字记数测验评分对比,并做统计学分析。结果(1)多灶LCI组与单灶LCI组比较在所有测验上评分均显著降低(P<0.05)。(2)左侧梗死组在数字排序评分上明显低于右侧梗死组(P<0.05);右侧梗死组在Corsi模板任务测验评分上明显低于左侧梗死组(P<0.05);左右两侧梗死组在视觉广度测验和Stroop数字记数测验评分上比较无显著性差异(P>0.05)。结论多灶LCI患者工作记忆损害较单灶LCI患者显著,左侧梗死导致言语工作记忆损害,右侧梗死导致空间工作记忆损害,客体工作记忆与左右两侧梗死均有关,提示工作记忆不同成分在生理结构上存在大脑左右两侧不对称效应。

Objective To study the characteristics of working memory impairment in patients with lacunar cerebral infarctions （LCI）. Methods 42 patients proved by clinics were chosen, and divided into two groups： multiple and single LCI groups, versus left , right and double side infarction groups. Their working memory status were evaluated and compared with Digit Ordering Test, Corsi block task, House Visual Span Test and Stroop Digit Counting Test. All scores were analyzed statistically. Results （ 1 ） All scores of the four types of Tests in multiple LCI group were significantly lower than those in single group （ P 〈 0.05 ）. （ 2 ） The patients in left infarction group had lower scores than those in right group with Digit Counting Test （ P 〈 0.05 ）. The patients in right infarction group had lower scores than those in left group with Corsi block task （ P 〈 0.05 ）. There were no significant differences between the patients in left and right infarction group with House Visual Span Test and Stroop Digit Counting Test（ P 〉 0.05 ）. Conclusions Multiple LCI is closely related to working memory impairment. Left brain infarction may induce verbal working memory impairment, and right infarction may induce spatial working memory impairment, but object working memory impairment may related to double side of brain infarction . It suggested that in the physiological structure ,different components of working memory regions had dissymmetrical effect in two sides of brain.