摘要
目的明确氨基甙类抗生素致聋（ＡＡＩＤ）有无遗传基础及其遗传方式。方法调查测出上海市闸北区ＡＡＩＤ的患病率并绘制谱系图。结果ＡＡＩＤ患病率为３．５／万；具有阳性家族史的ＡＡＩＤ患病率为９．７／１０万，分析其３６个家系显示，对抗生素耳毒性的敏感性全部由女性遗传；重复分析了１５个由其他学者已发表的家系也证实了这个结论。结论ＡＡＩＤ属线粒体遗传，对具有ＡＡＩＤ家族史的个体（尤其是母系亲属），应当避免使用氨基甙类抗生素。
Objective To study the genetic background and its inheritance mode of aminoglycoside antibiotic induced deafness(AAID). Methods A survey of the prevalence of AAID in Zhabei District of Shanghai was made together with its pedigree charts. Results The prevalence rate of AAID was 35 per 100 000. The prevalence rate of AAID with a positive family history was 9.7 per 100 000. All of the 36 pedigrees had in common that the transmission of susceptibility to antibiotic ototoxicity was exclusively through females. Reanalysis of 15 other published pedigrees also confirmed above conclusion. Conclusion The inheritance mode of AAID is mitochondrial inheritance. Aminoglycoside antibiotic therapy should be avoided in those persons with a family history of AAID, especially their maternal relatives.
