国产曲尼司特抗过敏作用的实验研究

Antiallergic Effects of Tranilast in Rats and Guinea Pigs

以日本Ｋｉｓｓｅｉｓ公司产的曲尼司特为对照，对华西医科大学药学院新合成路线合成的曲尼司特的抗过敏作用进行了研究。结果显示：华西产曲尼司特能明显抑制大鼠ＰＣＡ反应和豚鼠Ｓｃｈｕｌｔｚ－Ｄａｌｅ反应，能有效地稳定肥大细胞膜，阻止肺组织释放ＳＲＳ－Ａ及对抗ＳＲＳ－Ａ引起的收缩反应，而且作用强度与日本产曲尼司特相似。

Tranilast is an anti allergic drug.In this study,we made a comparision between the Tranilast synthized by School of Pharmacy WCUMS using new technical and the Tranilast produced by Kissei pharmaceutical Co.LTD,Japan on their antiallergic effects.We found that the two tranilasts had the same antiallergic effects:(1) they inhibit the passive cutaneous anaphylaxis in sensitized rats with the dose of 100,200mg/kg( P <0.01);(2)they inhibit degranulation of mast cells in sensitized rats (10 -5 and 10 -4 mol/L) ( P <0 05);(3)they inhibit schultz Dale response in sensitized guinea pigs (10 -3 and 10 -4 mol/L);(4)the inhibit SRS A release from the lung of sensitized guinea pigs(10 -3 ,10 -4 and 10 -5 mol/L) ( P <0.05);and (5) they inhibit the contraction of ileum of normal guinea pigs induced by SRS A(10 -4 and 10 -3 mol/L).