乳腺癌C-erbB-2癌基因与雌激素和孕激素受体的关系及其临床意义

Relationship of C erbB 2 Oncogene Overexpression to Estrogen Progesterone Receptors in Brease Cancer and Its Prognostic Significance

为探讨乳腺癌Ｃ－ｅｒｂＢ－２癌基因与雌激素和孕激素受体的关系及其临床意义，采用ＬＳＡＢ免疫组化法对１０６例乳腺癌标本进行Ｃ－ｅｒｂＢ－２癌基因的检测。结果：Ｃ－ｅｂｒＢ－２表达阳性率为６３．２％（６７／１０６），对生存时间≤５年及＞１０年者，其Ｃ－ｅｒｂＢ－２表达阳性率分别为８１．６３％和３４．２９％，表明Ｃ－ｅｒｂＢ－２癌基因过度表达与乳腺癌的临床分期晚、组织学分级高、腋窝淋巴结转移有关，并与雌激素、孕激素受体状况呈负相关。由此提示Ｃ－ｅｒｂＢ－２癌基因的过度表达是判断乳腺癌预后的一个重要因素，宜将Ｃ－ｅｒｂＢ－２癌基因列为乳腺癌的常规检测指标之一。

In order to understand the relationship of C erbB 2 oncogene overexpression to ER and PR in breast cancer and its prognostic significance, we examined overexpression of C erbB 2 oncogene in 106 breast carcinomas by using immunohistochemical techniques (LSAB). The results showed that the positive rate of C erbB 2 overexpression was 63.21% (67/106). The overexpression of C erbB 2 oncogene related negatively with survival. 81.63% of the cases with overexpression of C erbB 2 oncogene survived ≤5 yeras and 34.29% survived >10 yerars. There were significant associations of C erbB 2 overexpression with advance clinical stage, high histological grade, and positive axillary node status in breast cancers. Negative relatioship between hormone receptors and C erbB 2 oncogene. All of these findings suggested that overexpression of C erbB 2 oncogene might be an important prognostic factor and the detection of C erbB 2 oncogene might be arranged as a regular pathological examination in the cases of breast cancer.