抑肽酶对肝素化全血激活的全血凝固时间和全血凝血酶原时间的影响

EFFECTS OF APROTININ ON HEPARINIZED WHOLE BLOOD ACTIVATED CLOTTING TIME AND WHOLE BLOOD PROTHROMBIN TIME

用体外血液凝固法观察了不同浓度的抑肽酶（ａｐｒｏｔｉｎｉｎ）对肝素化血液激活的全血凝固时间（ＡＣＴ）和全血凝血酶原时间（ＢＰＴ）的影响。结果显示：用高岭土作激活剂时抑肽酶也能延长ＡＣＴ时间，且与肝素有明显的协同作用（Ｑ＝０．７５７＜１）；但抑肽酶与肝素联用时对外源性凝血途径无影响，不影响ＢＰＴ时间。

When aprotinin is used during cardiopulmonary bypass, there is a prolongation of the activated clotting time (ACT), which is used to monitor heparinization. The aim of this study was to observe the effects of aprotinin and heparin on whole blood ACT and whole blood prothrombin time (BPT). The results showed that when kaolin was used as the contact activator, the intrinsic clotting system was also inhibited by aprotinin, the observed ACTs with various dose aprotinin and concomitant heparin were significantly prolonged (Q=0.757,P<0.01). There was a dose dependent prolongation of BPT by heparin (r=0.985,P<0.01). However, the heparin mediated prolongation of BPT was not enhanced by aprotinin. The authors conclude that aprotinin prolongs heparinized whole blood activated clotting time but was not whole blood prothrombin time.