代谢组学与天然药物和中药研究

Metabonomics in Research of Natural Drugs and Traditional Chinese Medicines

代谢物组学是后基因时代出现的一门新兴"组学"学科,它能用反映整体的代谢物图直接认识生命体的生理和生化状态,因此能提供区别于其他"组学"而来的大量信息。在天然药物和中药研究中,应用代谢组学研究的方法和技术具有广泛的前景,特别是在药物作用机制、靶器官的效应、新药筛选、安全性研究等方面具有理论意义和应用价值。

Metabonomics is a new ＂-omics＂ sicience in post-gene time. Metabonomics can be directly applied to understand the physiological and biochemical situation by its ＂metabolome profile＂ as a whole. Therefore it can provide a loft of informa- tion that differed from those came out of other ＂-omics＂. Metabonomics has been used to evaluate test animal models and to evalu- ate disease models, action mechanism of drugs, target response, drug safety and screening of new drugs. Therefore, metabonomics is hopeful to be necessary part on research of natural drugs and traditional Chinese medicines.