食管鳞癌发生过程中nm23-H_1蛋白的表达

Expression of nm23 H 1 during the carcinogenesis and development of human esophageal squamous cell carcinoma

应用免疫组化ＬＳＡＢ技术对６３例食管鳞癌及癌旁粘膜进行ｎｍ２３Ｈ１蛋白表达检测。结果：阳性表达产物主要位于细胞浆；随着癌旁粘膜病变程度的加重，ｎｍ２３Ｈ１表达呈下降趋势，且轻度病变与重度不典型增生，原位癌及鳞状细胞癌之间差异有显著性；食管鳞癌分化越差，ｎｍ２３Ｈ１表达越低（Ｐ＜０．００５）；非转移组ｎｍ２３Ｈ１蛋白表达率明显高于转移组（Ｐ＜０．０５）。提示：ｎｍ２３Ｈ１在人食管鳞癌发生发展过程中起重要的抑制作用。

With immunohistochemical LSAB technique,we examined the expression of nm23 H 1 in 63 cases of esphageal squamous cell carcinoma and their pericancerous mucosa.The positive cells were mainly seen in cytoplasmic staining.With the increase of severity of lesions in pericancer mucosa,nm23 H 1 expression decreased accordingly.The carcinoma tissue had a 26.98% expression rate.The inverse correlation could be seen between nm23 H 1 expression and the carcinoma differentiative degrees.We also observed the significant inverse correlation between the nm23 H 1 expression and the lymphic metdstatic rate.The results indicated that nm23 H 1 might play an important role in the carcinogenesis and development of human esophageal squamous cell carcinoma.