AZ31B镁合金植入小鼠的生物相容性考察

Study on Biocompatibility of AZ31B Magnesium Alloy in Mice

目的:评价羟基磷灰石(hydroxyapatite,HAP)涂层的AZ31B镁合金(HAP/AZ31B)作为植入材料的生物安全性。方法:采用恒电压阴极电沉积法制备表面HAP涂层的HAP/AZ31B材料;判定生物材料的致突变及毒性作用;检测材料表面的腐蚀状况并进行能谱分析。结果:HAP/AZ31B材料无致突变作用,对动物组织未产生严重的炎症反应;经HAP涂层后的AZ31B材料腐蚀较慢,微核出现率为4.4‰,溶血率为0.25%。结论:HAP/AZ31B表现出较好的生物安全性和相容性,有可能成为新型可降解骨支架材料。

Objective： to evaluate biological safety of HAP/AZ31B as implanted material. Methods： HAP/ AZ31B biomaterial was prepared by cathodic electrodeposition with constant voltage technique, and then biocompatibility was assessed. The corrosion of surface was detected by spectrum analysis. Results ： HAP/AZ31 B had no mutagenesis and toxic effect. Serious inflammatory reaction was not induced. The corrosion velocity of HAP/AZ31B was slower. The micronucleus frequency and hemolysis of HAP/AZ31 B leaching liquor was 4.4‰ and 0.25%, respectively. Conclusion： HAP/AZ31B had excellent biological safety and biocompatibility, which would be a new degradable and biomedical material.