夹脊平衡电针治疗腰椎间盘突出症的临床研究

Clinical study on treatment of Jiaji-balance-electroacupuncture in patients with lumbar disc herniation

目的:观察夹脊平衡电针治疗腰椎间盘突出症(LDH)的临床疗效及其对血浆β-内啡肽(β-EP)含量与自由基(oxygen free radicals,OFR)代谢的影响。方法:将68例LDH患者随机分为治疗组36例和对照组32例进行比较,采用杨氏评分法评定疗效,并分别于治疗前、后测定患者血浆β-EP、超氧化物歧化酶(SOD)、丙二醛(MDA)与谷胱甘肽过氧化物酶(GSH-PX)的含量。结果:治疗组优良率明显优于对照组,差异具有显著性意义(P<0.05)。治疗后两组血浆β-EP、SOD、GSH-PX均较治疗前增高,MDA含量均较治疗前降低,差异均有显著性意义(P<0.01、P<0.05)。两组治疗前后血浆β-EP、SOD、MDA、GSH-PX差值相互比较,差异有显著性意义(P<0.01)。结论:夹脊平衡电针治疗腰椎间盘突出症具有良好的临床疗效,并可提高患者血浆β-EP、SOD、GSH-PX活性、降低MDA水平,增强机体抗氧化能力,减轻自由基的损害,这可能是电针作用机制之一。

Objective：To observe the therapeutic effects and influence on the levels of plasma β-endorphin （β-EP） and oxygen free radicals（OFR） of Jiaji-balance-electroacupuncture in patients with LDH. Method：Sixty-eight cases of LDH were randomly divided into treatment group （n=36） and control group （n=32）. The therapeutic effects were assessed with Yang＇s quantitative evaluation scale. The levels of plasma β-EP and OFR such as SOD and MDA as well as GSH-PX were measured before and after treatment. Result： The quantitative clinical improvement was obviously better in treatment group as compared with control group with significant differences （P〈0.05）. The levels of plasma MDA reduced significantly, the levels of plasma β-EP and SOD as well as GSH-PX elevated（P〈0.01, P〈 0.05） in the two groups after treatment, and these changes in plasma were significantly in treatment group as compared with control group （P〈0.01）. Conclusion： Jiaji-balance-electroacupuncture display better therapeutic effects, elevate the activities of plasma β-EP and SOD as well as GSH-PX, reduce the levels of MDA, increase the capacity to alleviate the damage by OFR, which maybe one of the mechanisms of action of electroacupuncture in patients with lumbar disc herniation.