胰岛素样生长因子结合蛋白3和特发性肺纤维化

Insulin-like growth factor binding protein-3 and idiopathic pulmonary fibrosis

特发性肺纤维化（IPF）是原因不明但发病率和病死率明显的纤维变性疾病，在肺纤维化过程中，众多细胞因子参与了细胞调控，其中胰岛素样生长因子结合蛋白3（IGFBP-3）被发现与IPF有关，但其具体作用机制还不明了。许多学者发现IGFBP-3可以通过依赖性和非依赖性地方式结合IGF，但具体的IGFBP-3信号传导通路还没完全阐明。越来越多的研究显示出IGFBP-3这种蛋白在人体多器官中的重要作用，近年来研究者们把目光聚焦在肺上，而且有关纤维化的相关研究逐渐浮出水面。但其作用机制尚不清楚，阅览国内外有关报道，可能与以下内容相关：①IGFBP-3的生长抑制和细胞凋亡作用；②IGFBP-3与IGF-1；③IGFBP-3与TGF—β1；④IGF-1与TGF-β1；⑤IGFBP-3与细胞外基质。由此可见，IGFBP-3与IPF有着潜在的必然关系，IGFBP-3在促IPF的形成扮演着重要角色。

Idiopathic pulmonary fibrosis（IPF） is a fibrous degeneration disease whose etiopathogenisis is unclear,but incidence and case fatality is prominent. During the fibrous degeneration, a lot of cytokines take part in cell regulation. Insulin-like growth factor binding Protein-3（IGFBP-3） is discovered to be related with IPF. But its concrete mechanism of action is unclear. Many scholars have discovered IGFBP-3 can bind with IGF by dependent or non-dependent mode, but the concrete IGFBP-3 signal transduction pathway has not been elucidated completely. More and more studies have shown IGFBP-3 exerts very important role in many body organs and scholars put emphasis on the pulmonary fibrosis study in recent years. But the concrete mechanism of this action is not so clear,according to relative reports,maybe it is relative to aspects below：（1）growth inhibiting of IGFBP-3 and apoptosis; （2）IGFBP-3 and IGF-1; （3）IGFBP-3 and TGF-β1; （4） IGF-1 and TGF-β1; （5） IGFBP-3 and extracellular matrix. So potential and inevitable association exists between IGFBP-3 and IPF,IGFBP-3 has important role in pulmonary fibrosis;