米氮平和氟西汀治疗老年期抑郁症的疗效比较

Efficacy of Mirtazapine and Fluoxetine in Eldly Depressed Patients

目的:观察米氮平对老年期抑郁症患者的疗效及不良反应。方法:将符合入组标准的82例患者随机分为米氮平组41例,氟西汀组41例。于治疗前和治疗后第1、4、8周末采用汉密顿抑郁量表(HAMD)17项评定疾病严重程度和疗效;采用不良反应量表(TESS)评定药物不良反应。结果:米氮平组有效率达87.8%,氟西汀组有效率达80.5%;两组疗效差异不显著。在治疗第1周末及第8周末,两组间HAMD总分差异有显著性(P<0.05)。食欲增加和睡眠障碍的发生率两组间差异有显著性。结论:米氮平治疗老年期抑郁症起效快,抗抑郁作用强,改善睡眠好,不良反应少。

Objective： To study the efficacy and safety of mirtazapine and fluoxetine in eldly depressed patients. Method： A 8 -week double -blind study was conducted with 82 eldly depressed patients. Subjects were randomly assigned to either mirtazapine （n = 41 ） or fluoxetine （n = 41 ）. All subjects were evaluated with hamilton rating scale for depression - 17 （ HAMD - 17 ）, and treatment emergent symptom scale （TESS） at baseline, the end of weekl ,4 and 8 after treatment. The study had lasted for 8 weeks. Result： The response rate between two groups （ mirtazapine 87.8 vs fluoxetine 80.5 ） was similar. There were significant differences on the scores of HAMD between the two groups at the end of lth and 8th week, The rates of side effects on increased food appetite and sleep disorder were greatly different between the two groups. Conclusion：Mirtazapine has rapid response , strongly antidepressive effect in eldly depressed patients and less side effects.