木尘与肺癌关系的队列研究

A cohort study on lung cancer and exposure to wood dust

为进一步探讨木尘与肺癌的关系，我们进行了回顾性队列研究，暴露组为成都某木综厂工龄１年以上的接触木尘职工２３６２（男１７０７，女６５５）人，观察期１５年（１９７８年１月１日～１９９２年１２月３１日），观察了３３６７９人年。非暴露组为当地某煤矿工龄１年以上的男性职工２５８７人，观察期２１年（１９７２年１月１日～１９９２年１２月３１日），观察了５４０４０人年。结果显示：接触木尘职工肺癌的标化死亡率（ＳＭＲ）为７４．６２／１０５（ＲＲ＝４．０８，Ｐ＜０．０１），与当地居民死亡率比较，接尘职工的ＳＭＲ为２１８．６（９５％ＣＩ：１．４１～３．２３，Ｐ＜０．０１）。肺癌标准化死亡比例比（ＳＰＭＲ）为３４９．０，差异有非常显著意义（Ｐ＜０．０１）。提示：木尘可能与肺癌有关。

To further explore the relationship between lung cancer and exposure to wood dust,a retrospective cohort mortality study was conducted.A follow up survey was made from Jan 1,1978 to Dec 31,1992,on 2 362(male 1 707,female 655)wood workers(33 679 person years)employed at any time until 1977 by a wood processing factory of Chengdu in China and from Jan 1,1972 to Dec 31,1992,on 2 587 male workers(54 040 person years)employed at any time until 1971 by a native coal mine in the same area as unexposed group.The standardized mortality ratio (SMR) was 74.62/10 5( RR 4.08, P <0.01) from lung cancer (ICD 9,162).By comparison with the mortality rates in local residents,the SMR of exposed workers was 218.6(95% CI ,1.41￣3.23 P<0.01 ) from lung cancer.The standardized proportional mortality ratio( SPMR ) was 349.0 from lung cancer,significantly higher than SMR(P <0.01).