慢性淋巴细胞性甲状腺炎预后临床再分析

Further Clinical Analysis on the Prognosis of Chronic Lymphocytic Thyroiditis

本研究对300例慢性淋巴细胞性甲状腺炎患者进行随诊，发现有2例合并甲状腺乳头状癌，其发生率并不高；以甲状腺功能减低为首发症状者占643％，随诊过程中甲状腺功能低减的发生率为76％。统计分析表明，甲状腺功能低减的发生与抗甲状腺球蛋白抗体增高、甲状腺肿大及甲状腺疼痛等有关。

Objective and Methods There have been many reports on the incidence of hypothyroidism and thyroid carcinoma in chronic lymphocytic thyroiditis patients, however,the incidence of thyroid carcinoma had been a widely debated issue. Therefore 300 cases of chronic lymphocytic thyroiditis from 1964 to 1995 were reviewed. There were 37 males and 263 females, and 52 had a pathological diagnosis of chronic lymphocytic thyroiditis. Results Among 300 patients, 2 had coexistent thyroid papillary carcinoma. The original symptom in 64. 3% patients was hypothyroidism, and the total incidence of hypothyroidism was 76%. It was also indicated in this study that the occurrence of hypothyroidism in chronic lymphocytic thyroiditis patient was associated with the elevated level of antithyroglobulin antibody, enlargement and tenderness of thyroid gland. Conclusion In our study, as the low incidence of coexisted thyroid carcinoma, with the high incidence of hypothyroidism it seemed to be that the elevated antithyroglobulin antibody could be a more effective factor in the development of hypothyroidism in chronic lymphocytic thyroiditis.