检测细胞免疫功能指标评价2种尖锐湿疣治疗方法的效果

Evaluation on the Treatment Effect of Condyloma Acuminatum with Two Different Methods by Cellular Immune Function Detection

[目的]探讨检测细胞免疫功能评价2种尖锐湿疣治疗方法的效果。[方法]对2005年1月至2006年6月在聊城市人民医院皮肤性病科初次就诊的尖锐湿疣患者120例,采集病人的血清用免疫酶法测定T淋巴细胞亚群,计数200个细胞;采用双抗体夹心(ELISA)方法测定白介素2(IL-2)、可溶性白介素2受体(SIL-2R)。[结果]采用A方法治疗尖锐湿疣患者(A组),治疗后与治疗前比较,患者的CD4+细胞百分比、CD4+/CD8+比值、血清IL-2水平升高,CD8+细胞百分比、血清SIL-2R水平降低,与B方法(B组)CD3+的差异无统计学意义(P>0.05);CD4、CD4+/CD8+高于B组,CD8低于B组,IL-2高于B组,SIL-2R低于B组,差异均有统计学意义(P<0.01)。[结论]检测外周血CD4+、CD8+、CD4+/CD8+和血清IL-2是评价治疗尖锐湿疣效果的有用的细胞免疫功能指标,对尖锐湿疣患者选择治疗方法可提供一定的依据,对病情的发展和疾病的预后能提供一定的帮助。

[-Objective]To appraise the effect of two different therapies in condyloma acuminatum treatment by cellular immune function detection, [Methods]The serum was collected from 120 patients with condyloma acuminatum which first visited in People＇s hospital of Liaocheng between January 2005 to June 2006. The level of the subpopulation of T lymphoCyte was tested by immunoenzyme method in peripheral blood and the level of IL-2 and SIL-2R in serum were tested by ELISA assay. [Results]After treatment, the level of CD4 ^＋ cell,IL-2, CD4 ^＋/CD8^＋ raised, CD8^＋ , SIL-2R reduced in group A patients compared with group B patients. There was no different between two groups （ P 〉0. 05）;The results by the detection of serum in group A showed that,the CD4^ ＋ cell, CD4^ ＋/CD8^ ＋ reduced,the amount of CD8^ ＋ cell raised. IL-2 reduced and SIL-2R is raised, There was a different of results between two groups （ P 〈0.01）. [Conclusion]The cellular immune function detection which included the CD4^ ＋ cell, CD4 ^＋/CD8^ ＋ , IL-2, SIL-2R has valuable indication to appraise the effect of two different therapy methods in condyloma acuminatum,it can not only provide basement of the different treatment method in condyloma acuminatum,but also offer help in the development and prognosis of the disease.