散发性急性戊型肝炎血清抗体动态变化和肝脏超微结构的病理观察

Dynamic changes of serum antibody titer and liver ultrastructural pathology in acute sporadic hepatitis E virus infected patients

为探讨散发性戊型肝炎血清抗体动态变化，应用酶联免疫法（ＥＩＡ）检测了７例急性戊型肝炎患者抗戊型肝炎病毒（ＨＥＶ）ＩｇＧ和ＩｇＭ抗体，并对１例患者进行了肝超微结构病理检测。结果表明，发病后１０天至４５天内抗ＨＥＶ－ＩｇＧ和ＩｇＭ滴度最高，发病第４０天仍有肝细胞肿胀，胞浆空化和线粒体固缩等病理变化。患者血清抗－ＨＥＶＩｇＭ滴度在４５天后逐渐下降，２个月内全部消失，抗－ＨＥＶＩｇＧ消长情况与ＩｇＭ相似，但在７个月时仍有３例（４３％）抗体阳性。

acute hepatitis E patients were tested for anti HEV IgM and IgG antibodies by EIA. It revealed that anti HEV IgM and IgG antibody titers were the highest at day 10-45 of the illness, and anti HEV IgM declined gradually and totally lost within 2 months. Anti HEV IgG had a similar condition to anti HEV IgM, but at 7th month there still had 3 cases (40%) remained to be antibody positive. One case was examined for ultrastructural pathology. The swelling of liver cells on the fortieth day of illness was still to be found, the vacuolation of cytoplasm and condensation of mitochondria were present in liver cells.