吗啉胍,大蒜素,α-干扰素及其联合应用对呼吸道合胞病毒的抑制作用

Inhibition of respiratory syncytial virus(RSV) by Moroxydine, Allicin, α interferon and their joint application

研究了吗啉胍、大蒜素和α－干扰素及其联合应用对呼吸道合胞病毒（ＲＳＶ）的抑制作用，结果３种药物各自在ＨｅＬａ细胞上对ＲＳＶ都有抑制作用。吗林胍的有效剂量为１００ｍｇ／Ｌ，大蒜素为纯品的１／８×１０５浓度，α－干扰素为１．５×１０４Ｕ／Ｌ。当３种药物配伍联合应用时，均可产生协同作用，既可降低用药量，减少毒副反应，又可有效地抑制ＲＳＶ的感染。

This paper reported the inhibition of respiratory syncytial virus by Moroxydine (ABOB), Allicin, α interferon and their joint application. The results indicated that each of the three drugs inhibited RSV in HeLa cells, and the effective dosage of ABOB was 100mg/L, α interferon 1.5×10 4U/L and Allicin one eight hundred thousandth of the pure material. The combinations of 3 drugs showed synergism without antagonism, this not only decreased the dosage, toxicity but also enhanced the inhibition effects on respiratory syncytial virus obviously.