固有免疫模式识别受体与药物研究

Pattern-recognition receptors and drug research

固有免疫细胞可通过模式识别受体直接识别和结合病原体病原相关分子模式而被激活,启动机体免疫防御反应,在识别和清除病原体的过程中起重要的作用。文中介绍了2种重要的固有免疫识别受体Toll样受体(Toll like receptors,TLRs)和核苷酸结合寡聚化结构域(nucleotide binding oligomerzation domain,NODs)受体家族,论述了感染性疾病、过敏性疾病、自身免疫性疾病、肿瘤、中枢神经系统疾病等与模式识别受体的关系和相关的药物研究靶点,并介绍了TLRs为靶点的药物和NOD2配体胞壁酰二肽(muramyldipeptide,MDP)衍生物的研究现状和应用前景。

Innate immune cells can be activated by recognizing the pathogen-associated molecular pattern （PAMPs） through pattern-recognition receptors （PRRs）. The PRRs have important functions in pathogen recognition and clearance. In this review, the Toll-like receptors （TLRs） family and nucleotide binding oligomerization domain （NODs） family were introduced, and the important roles of PRRs in infection, inflammation, allergy, autoimmune disease, cancer and neurodegenerative diseases and the possibility of therapeutic targeting PRRs were discussed. The current research status and potential application of drugs targeting TLRs and NOD2 agonists were also commented.