摘要
目的:以L-苏氨酸为起始原料,经N-Boc保护合成氨曲南。方法:以L-苏氨酸为原料,经酯化、氨解、氨基保护、保护羟基、磺化、环合、脱保护7步反应,制得氨曲南主环,并最终合成氨曲南。结果和结论:目标化合物经核磁共振氢谱确证其化学结构,收率60.4%(以氨曲南主环计)。该法工艺简单,反应效率提高。
Objective: To synthesize aztreonam starting from L-threonine via N-Boc protection. Methods: Started from L-threonine, the main-ring of aztreonam was prepared via esterification, aminolysis, and subsequent protection of amino group and hydroxyl group, sulfonation, cyclization, and deprotection. Results and conclusion : The structure of aztreonam was verified by ^1H NMR. The overall yield was 60.4% (the main-ring of aztreonam). This method is simple and has higher efficiency.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2008年第5期393-395,共3页
Chinese Journal of New Drugs