补骨脂血清药物化学的初步研究

Pilot study on serum pharmacochemistry of fructus psoraleae

目的:应用血清药物化学方法研究补骨脂的活性成分。方法:通过比较空白血清、含药血清、甲醇提取物HPLC图谱的差异,对补骨脂的活性成分进行快速筛选和分析。结果:含药血清有重复出现的特征峰,与甲醇提取液的图谱对比在相应保留时间出峰,紫外光谱类似。结论:用血清药物化学的方法对中药的血清药源性成分进行分析可初步明确药材中众多化学组分在体内的吸收情况。

Objective： To investigate the active components in fructus psoraleae as determined by serum pharmacochemistry. Methods： From the differences in HPLC fingerprints of blank serum, serum containing drug and methanol extract, the active components in Fructus psoraleae were screened and analyzed. Results： The characteristic peaks appeared repeatedly in Fruetus psoraleae-containing serum, and the retention time was the same as that in the methanol extract. These peaks were absent in blank serum. Conclusion： The absorbed chemical components from medical materials, such as Fructus psoraleae, can be identified initially throughout analyzing components by serum pharmacochemistry.