肝炎后肝硬化SAAG与EV程度的关系

Correlation between SAAG and EV in Patients with Hepatiets Cirrhosis

目的通过对有EV和腹水的肝炎后肝硬化患者SAAG测定并研究SAAG与EV程度的关系,了解是否可以通过SAAG来推断肝炎后肝硬化的EV程度。方法选择896例经胃镜证实有EV(分为轻、中、重度),同时合并有腹水的肝炎后肝硬化患者。按EV程度分3组(A、B、C),分别测定SAAG,探讨SAAG与EV程度的关系。结果肝炎后肝硬化患者SAAG与EV程度的关系。A组:轻度EV,SAAG=(12.9±4.5)g/L;B组:中度EV,SAAG=(16.0±4.5)g/L;C组:重度EV,SAAG=(28.2±8.1)g/L。B组与A组比较P<0.05,C组与B组比较P<0.01。SAAG愈高,则肯定有EV存在,且曲张程度愈重。结论通过对肝炎后肝硬化腹水患者SAAG及EV程度关系的研究,可以得出以下结论:有腹水和EV的肝炎后肝硬化患者均有高SAAG,SAAG>11g/L,最高可达36.3g/L,SAAG越高,EV程度越重。SAAG可以作为肝炎后肝硬化EV程度判定的指标。

Objective To study the relationship between SAAG and EV by determining SAAG and diagnosing EV using endoscopy in the patients of hepatitis cirrhosis with both of EV and ascites. Methods 896 patients of hepatitis cirrhosis with EV and asciles were studied. According to the degree of EV which were revealed by electronic endoscopy, they were divided into three groups, group A（light-degree, n=318）, group B（middle-degree, n=298）, and group C（severe-degree, n=280）. The albumin contents in serum and ascites were measured and SAAG values were calculated（SAAG=serum albumin-ascites albumin） in all patients and the correlation between SAAG and EV was investigated. Results The correlation of SAAG and the degree of EV. The SAAG of Group A, B and C was （12.9±4.5）g/L, （16.0±4.5）g/L and （28.2±8.1）g/L respectively. There was difference between group B and A （P〈 0.05）, and between group C and B （P〈0.01）. The higher SAAG is, more severe EV degree may be. EV exists certainly in the patients with high SAAG. Conclusion All patients with ascites and EV of hepatitis cirrhosis have high SAAG （〉11g/L） and the highest reached 36.3 g/L. The higher SAAG was, the more severe of EV was. So SAAG can be considered as an index to evaluate the degree of EV in the hepatitis cirrhosis.