替米沙坦与赖诺普利治疗原发性高血压疗效比较

Comparison of Efficacy of Telmisarten Versus Lisinopril in Essential Hypertension

目的评价替米沙坦治疗原发性高血压患者的疗效。方法132例轻中度原发性高血压患者采用随机双盲的研究方法分为替米沙坦组(n=68)和赖诺普利组(n=64),分别接受替米沙坦40mg/d或赖诺普利10mg/d,1周后血压控制不满意者(收缩压≥140mmHg,舒张压≥90mmHg),接受替米沙坦80mg/d或赖诺普利20mg/d。结果替米沙坦与赖诺普利均能有效降低血压,治疗总有效率分别为60.3%和64.1%,降压程度及治疗有效率比较无显著性差异(P>0.05)。替米沙坦组具有良好的耐受性,未见干咳现象,而赖诺普利组干咳现象发生率达5.6%。结论替米沙坦是治疗轻中度原发性高血压安全、有效的药物。

Objective To evaluate efficacy of Telmisarten in the treatment of essential hypertension. Methods 132 patients with mild and moderate hypertension were randomly divided into Telmisarten 40mg/d and Lisinopril 10mg/d,which could be increased to 80mg/d and 20mg/d if blood pressure control was not satisfied. Results Both Telmisarten and lisinopril were effective at lowering blood pressure. 60.3% and 64.1% of patients in each group were considered to be effective at 2 weeks with no statistically significant differences between the two groups. Both drugs were well tolerated. 5.6% of the patients in lisinopril group had dry cough but not in Telmisarten group. Conclusion Telmisarten is effective and well-tolerated with less side effect in treatment of patients with essential hypertension.