兰索拉唑与云南红药胶囊联合应用对慢性糜烂性胃炎疗效观察

Observation of the Efficacy of Lansoprazole Associated with Chinese Medicine Yunnan Hong Yao in the Treatment of Chronic Erosive Gastritis

目的探讨兰索拉唑联合云南红药胶囊治疗慢性糜烂性胃炎的疗效。方法连续收集门诊就诊患者100例纳入临床观察,随机均分为兰索拉唑组、兰索拉唑加用云南红药胶囊组。兰索拉唑为15mg/次,每天2次;云南红药为3粒/次,每天3次。疗程均为14d。治疗前后分别行症状评分并复查胃镜。结果与治疗前比较,兰索拉唑组症状腹痛缓解率为77.1%,腹胀缓解率65.0%,上腹不适缓解率为66.7%;兰索拉唑加用云南红药胶囊组腹痛缓解率为88.5%,腹胀缓解率为78.3%,上腹不适缓解率为77.8%,总症状缓解率较单用兰索拉唑高(P<0.05)。治疗后,兰索拉唑组与兰索拉唑加用云南红药胶囊组的胃镜下粘膜糜烂总有效率分别为90%、98%,后者有更高的粘膜糜烂愈合能力(P<0.05)。两组均未见副作用。结论兰索拉唑加用云南红药胶囊有利于慢性糜烂性胃炎的粘膜糜烂的愈合及症状改善。

Objective To explore the efficacy of lansoprazole associated with chinese medicine Yunnan hong yao in treatment of the chronic erosive gastritis. Methods 100 out-patients with chronic erosive gastritis charactered by negative infection of H pylori were included. All cases were divided into two test group randomly and equally. One was treated with lansoprazole and another was treated with lansoprazole plus chinese medicine Yunnan hong yao. Lansoprazole 15mg twice per day. Yunnan hong yao 3 capsule three times per day. Total treatment course was 14 days. The total scores of abdominal pain,abdominal distension and epigastric discomfort as well as endoscopic examination were conducted before and after the treatment. Results The remission rate of abdominal pain was 77. 1% , abdominal distension 65.0%,epigastric discomfort 66.7% in lansoprazole group after treatment. However,in lansoprazole plus chinese medicine Yunnan hong yao group,they were 88.5% ,78.3% ,77.8% ,respectively. The total remission rate of symptoms in lansoprazole was lower than that in lansoprazole plus chinese medicine Yunnan hong yao. In additlon,the reeovery rate of mucosal erosion in lansoprazole were 90% ,98% in lasoprazole plus chinese medicine Yunnan hongyao. And lansoprazole plus chinese medicine Yunnan hong yao could get better recovery of mucosa. onclusion Lansoprazole plus chinese medicine Yunnan hong yao is beneficial for recovery of erosive gastric mucosa and improvement of dyspepsia.