绿茶及与相关因素的交互作用对大丰市居民肺癌发生的影响

The effect of green tea and its possible interactions with relevant factors on lung cancer in Dafeng county,Jiangsu province,China

目的:分析江苏省恶性肿瘤高发区大丰市人群中绿茶饮用及其与吸烟、饮酒和暴露于烹调油烟等危险因素间交互作用对肺癌发病的影响。方法:在江苏省恶性肿瘤高发区大丰市进行以人群为基础的病例对照研究,共收集523名肺癌病例和1924名健康对照,通过面对面询问的方式填写调查表。数据分析采用单因素和调整可能混杂因素的多因素非条件Logistic回归分析,对饮用绿茶与肺癌发病危险之间的关联,以及饮用绿茶与其他危险因素间的交互作用分别进行分析。结果:规律饮用绿茶可使肺癌发病危险显著降低[调整OR值(ORAdj)=0.520,95%可信区间(CI):0.392～0.691];并且肺癌发病危险有随着开始规律饮绿茶年龄减小而降低的趋势(PforTrendAdj<0.0001)。交互作用分析显示,规律饮绿茶分别与曾经吸烟、总吸烟量≥30包·年、曾经饮酒以及经常暴露于烹调油烟等因素间存在交互作用,尤其与曾经吸烟和总吸烟量≥30包·年间存在较强的交互作用,其可显著降低吸烟者肺癌的发病危险,ORAdj分别为0.575(95%CI:0.425～0.777)和0.706(95%CI:0.500～0.999)。结论:长期规律饮用绿茶对江苏省恶性肿瘤高发地区肺癌高危人群具有明显的保护作用,可以用于肺癌的化学预防。

Objective：To study the effects of green tea and its possible interactions with relevant factors on the risk of lung cancer in Dafeng County,an area with high cancer incidence in Jiangsu Province,China. Methods：A population-based case-control study was carried out in Dafeng Country,523 newly diagnosed lung cancer cases and 1 924 health control subjects were recruited. Epidemiology data were collected by interviews using a standard questionnaire. Unconditional Logistic regression was applied for calculating crude odds ratio（ORcru） and adjusted odds ratio（ORAdj）. Results：A decreasing association between regular green tea drinking and lung cancer risk was observed with ORAdj of 0.520（95% CI-0.392～0.691）. Moreover,dose-response relationship between the age of first green tea drinking and risk of lung cancer was found （Pfor Trend Adj 〈 0.000 1 ）. There were interactions between regular green tea drinking and smoking history,total cigarettes consumptions （≥ 30 pack · year） , alcohol drinking and continual cooking oil exposure,respectively. Furthermore,there were significant interactions between regular green tea drinking and smoking history （ORAdj for interaction：0.575; 95% CI ： 0.425 ～0.777） and total cigarettes consumptions （≥30 pack. year） （ORAdj for interaction ： 0.706 ; 95% CI ： 0.500～0.999）, which reduced the risk of lung cancer. Conclusion：Regular green tea drinking could reduce the risk of lung cancer in high cancer incidence areas and could be used for lung cancer chemoprevention.