立体选择活性自由基聚合进展

Progress in Stereoselective Living Radical Polymerization

尽管人工大分子的合成已经取得了长足发展,特别是在多种活性自由基聚合技术出现后,合成大分子的分子量和拓扑结构得到了良好控制,但如果以结构精确、高度功能化的生物大分子为模型来看,就会发现人工大分子的完全裁制合成仍是一个重大挑战。本文首先简述了合成大分子与生物大分子的结构差异,以及合成大分子在活性聚合领域和立体选择聚合领域各自已经取得的进展,在此基础上,专门介绍了近年来同时对合成大分子的分子量、立体结构和区域规整性进行控制的尝试,特别是在立体选择活性自由基聚合领域的进展。

Although great progress has been made on the synthesis of artificial inacromlecules, especially the control of molecular weight and topology due to the advent of living radical polymerization techniques, the wholely tailored synthesis of artificial macromolecule keeps a great challenge, if using the well structured, highly functionalized biological macromolecule as model. In this review, the difference between the synthetic maeromolecule and biologicl macromolecule is roughly described, so is the respective progress made in the field of living polymerization and in the field of stereoselective polymerization, based on this, the recent attempt to simultaneous control of molecular weight, tacticity and regiospecificity is described in detail, especially the progress made from field of stereoselective living radical polymerization.