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结肠癌患者术前外周静脉血CD133阳性细胞数量与血清癌胚抗原及肿瘤进展的关系 被引量：1

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摘要 目的:比较不同Dukes分期结肠癌患者术前外周静脉血CD133阳性细胞数量及分析其与血清癌胚抗原(CEA)水平的相关性,探讨外周静脉血CD133阳性细胞水平与肿瘤进展的关系。方法:采用流式细胞仪对32例结肠癌患者(DukesA期7例,B期8例,C期10例,D期7例)术前或化疗前3d外周静脉血CD133阳性细胞数量进行测定。所有患者术前或化疗前常规监测外周静脉血清CEA。另采集7位成年健康志愿者血样作为对照组。结果:对照组与DuckesA～D期患者外周静脉血CD133阳性细胞数量(个/mL)分别为25660.7±6419、45255.6±13016、43643.4±12095、73699.1±15656与91527.3±45505,其中DukesC、D期患者细胞数量与对照组相比均有显著上升(均P<0.01)。DukesD期患者外周静脉血CD133阳性细胞的数量较DukesA、B、C3期患者均有明显升高(均P<0.05)。肿瘤分化程度较好的患者(Broders分级Ⅰ/Ⅱ级,12例)细胞数量(个/mL)少于分化程度差的患者(Broders分级Ⅲ/Ⅳ级,20例),分别为42305.33±10348.797和76797.70±31278.733,差异有非常显著性(P=0.001)。结肠癌患者的外周静脉血CD133阳性细胞数量与血清CEA水平呈显著正相关(r=0.648,P<0.001)。结论:结肠癌患者术前外周静脉血CD133阳性细胞数量与肿瘤进展密切相关。
作者 汪春良 夏良 孙玉岭
机构地区 浙江省富阳市人民医院普外科 浙江大学医学院附属第一医院心内科 浙江大学医学院附属第一医院普外科
出处 《实用医学杂志》 CAS 2008年第5期767-770,共4页 The Journal of Practical Medicine
关键词 结肠肿瘤 CDL33 癌胚抗原 肿瘤进展
分类号 R735.35 [医药卫生—肿瘤]
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参考文献18

  • 1Price A S. Primary and secondary prevention of eolorectal cancer [J].Gastroenterol Nurs, 2003, 26(2) :73-81.
  • 2金星林,崔现,许东哲,金文昊.血清标志物CA_(242)与CEA在大肠癌中的比较[J].中国肿瘤临床与康复,2002,9(5):44-45. 被引量：9
  • 3孙宝华,王岭,易军,王辉,王新友.人外周血内皮祖细胞的诱导、分化与鉴定[J].实用医学杂志,2006,22(6):611-613. 被引量：2
  • 4Ricci-Vitiani L, Lombardi D G, Pilozzi E, et al. Identification and expansion of human colon-cancer-initiating cells [J ]. Nature, 2007, 445(7123) : 111-115.
  • 5O'Brien C A, Pollett A, Gallinger S, et al. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice [J]. Nature, 2007,445(7123 ) : 106-110.
  • 6Bruno S, Bussolati B, Grange C, et al. CD133+ renal progenitor cells contribute to tumor angiogenesis [J]. Am J Pathol, 2006, 169 (6) : 2223-2235.
  • 7Ho J W, Pang R W, Lau C, et al. Significance of circulating endothelial progenitor cells in hepatocellular carcinoma [J]. Hepatology, 2006,44 (4) : 836-843.
  • 8Yu D, Sun X, Qiu Y, et al. Identification and clinical significance of mobilized endothelial progenitor cells in tumor vasculogenesis of hepatocellular carcinoma [J]. Clin Cancer Res, 2007,13 (13) : 3814-3824.
  • 9Lyden D, Hattori K, Dias S, et al. Impaired recruitment of bonemarrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth [ J ]. Nat Med, 2001,7 ( 11 ) : 1194- 1201.
  • 10Hilbe W, Dimhofer S, Oberwasserlechner F, et al. CD133 positive endothelial progenitor cells contribute to the tumour vasculature in non-small cell lung cancer [ J ]. J Clin Pathol, 2004,57 (9) : 965 - 969.

二级参考文献15

  • 1中华人民共和国卫生部医政司.中国常见恶性肿瘤诊治规范，第三分册[M].北京:北京医科大学，中国协和医科大学联合出版社,1991,6..
  • 2曹泽毅.中华妇产科学(下册)[M].4版.北京:人民卫生出版社,2002,1746(1549):1782-1772.
  • 3YEH S A,LEUNG S W,WANG C J.Postoperative radiotherapy in early stage carcinoma of the uterine cervix:treatment results and prognostic factors[J].Gynecol Oncol,1999,72(1):10-15.
  • 4林博章,藤井哲哉,山下剛,等.子宫癌頸癌にする Sentinel Lymph Node Biopsyに關する予備檢討[J].日本産婦人科學雜誌,2002,54(6):856-859.
  • 5MUROHARA T,IKEDA H,DUAN J,et al.Transplanted cord blood derived endothelial precursor cells argument postnatal neovasculari-zation[J].J Clin Invest,2000,105(11):1527-1536.
  • 6ASAHARA T,MUROHARA T,SULLIVAN A,et al.Isolation of putative progenitor endothelial cells for angiogenesis[J].Science,1997,275(5302):964-967.
  • 7SHI Q,RAFIL S,WU M H D,et al.Evidence for circulating bone marrow-derived endothelial cells[J].Blood,1998,92(2):362-367.
  • 8GEHLING V M,ERGUN S,SCHUMACHER U,et al.In vitro differentiation of endothelial cells from AC-133 positive progenitor cells[J].Blood,2000,95(10):3106-3112.
  • 9PEICHEV M,NAIYER A J,PEREIRA D,et al.Expression of VEGF-2 and AC-133 by circulating human CD34+ cells identifies a population of functional endothelial precursors[J].Blood,2000,95(3):952-958.
  • 10KALKA C,MASUDA H,TAKAHASHI T,et al.Vascular endothelial growth factor(165) gene transfer augment circulating endothelial progenitor cells in human subjects[J].Circ Res,2000,86(12):1198-1202.

共引文献12

同被引文献27

  • 1Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell [ J ]. Nat Med, 1997,3 ( 7 ) : 730 - 737.
  • 2Al-Hajj M, Wicha MS, Benito-Hemandez A, et al. Prospective identification of tumorigenic breast cancer cells [J]. Proc Natl Acad Sci USA,2003,100(7):3983 - 3988.
  • 3Hemmati HD, NaKano I, Lazareff JA, et al. Cancerous stem cells can arise from pediatric brain tumors [ J]. Proc Natl Acad Sci USA, 2003,100 ( 25 ) : 15178 - 15183.
  • 4O'Brien CA, Pollett A, Gallinger S, Dick JE. A human colon cancer cell capable of initiating turnout growth in immunodeficient mice [ J ]. Nature, 2007,445 ( 7123 ) : 106 - 110.
  • 5Ricci-Vitiani L, Lombardi DG, Pilozzi E, et al. Identification and expansion of human colon-cancer- initiating cells [ J ]. Nature ,2007,445 (7123 ) : 111 - 115.
  • 6Odoux C, Fohrer H, Hoppo T, et al. A stochastic model for cancer stem cell origin in metastatic colon cancer[J]. Cancer Res ,2008 ,68 (17) : 6932 - 6941.
  • 7Vermeulen L, Todaro M, de Sousa Mello F, et al. Single-cell cloning of colon cancer stem cells reveals a multilineage differentiation capacity [ J ]. Proc Natl Acad Sci USA, 2008,105 ( 36 ) : 13427 - 13432.
  • 8Boman BM,Huang E. Human colon cancer stem cells:A new paradigm in gastrointestinal oncology [ J ]. J Clin Oncol,2008,26 ( 17 ) :2828 - 2838.
  • 9Brabletz T, Jung A, Spaderna S, et al. Migrating cancer stem cells:An integrated concept of malignant turnout progression [ J]. Nat Rev Cancer,2005,5 (9) :744 - 749.
  • 10van de Wetering M, Sancho E, Verweij C,et al. The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells [ J ]. Cell,2002,111(2) :241 -250.

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实用医学杂志
2008年 第5期

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