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脂联素与脑血管疾病研究进展 被引量：2

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摘要 脂联素（adiponectin）是新近发现的一种由脂肪细胞特异性分泌的血浆激素蛋白，具有重要的能量糖脂代谢功能．不仅与肥胖、胰岛素抵抗、糖尿病密切相关，还在动脉粥样硬化过程中起着重要的调控作用。
作者 何亚丽 魏麓云
机构地区 南华大学第二附属医院神经内科
出处 《实用医学杂志》 CAS 2008年第5期873-875,共3页 The Journal of Practical Medicine
关键词 脂联素 脑血管疾病 细胞特异性 胰岛素抵抗 激素蛋白 代谢功能 调控作用 硬化过程
分类号 R743 [医药卫生—神经病学与精神病学]
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参考文献28

  • 1刘平,王砚青,卞茸文,赵健.原发性高血压患者血清脂联素水平的研究[J].实用医学杂志,2006,22(17):1982-1984. 被引量：7
  • 2周燕,苏珂,龙艳,于健,唐灵,胡永玲.2型糖尿病家系一级亲属血清脂联素与胰岛素抵抗的关系及其临床意义[J].实用医学杂志,2006,22(3):290-291. 被引量：4
  • 3Kharroubi I, Rasschaert J, Eizirik L, et al. Expression of adiponectin receptors in pancreatic beta cells [J]. Biochem Biophys Res Commun, 2003,312(4) : 1118-1122.
  • 4Chinetti G, Zamadski C, Fruchart J C, et al. Expression of adiponectin receptor in human macrophages andregulation by agonists of the nuclear receptor PPARalpha, PPARgamma, and LXR [J]. Biochem Biophys Res Commun, 2004,314 (1):151-158.
  • 5Hug C, Wang J, Ahmad N M, et al. Tcadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin [J]. Proc Natl Acad Sci U S A, 2004,101 (28) : 10308-10313.
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  • 7Arita Y, Kihara S, Ouchi N, et al. Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-vinding protein and regulates growth factor-induced common post receptor signal in vascular smooth muscle cell [J]. Circulation,2002, 105 (24) : 2893 -2898.
  • 8Matsuda M, Shimomura I, Sara M, et al. Role of adiponectin in preventing vascular stenosis: the missing link of adipovascular axis [J]. Biol Chem,2002,277 (40) : 37487-37491.
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  • 10Ouchi N, Kihara S, Arita Y, et al. Novel modulator for endothelial adhesion molecules : adipocytc-derived plasma protein adiponectin [J]. Circulation, 1999, 100(25) : 2473-2476.

二级参考文献46

  • 1各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380. 被引量：33020
  • 2CAMPS I, BIARNES J, FERNANDEZ-REAK J M, ct al. Insulin resistance and metabolic syndrome in first-degree relatives of patients with NIDDM [J]. Med Clin, 1999, 112(8):281 -284.
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  • 4LINDSAY R S, FUNAHASHI T, HANSON R L, et al. Adiponectin and development of type 2 diabetes in the Pima Indian population [J].Lancet, 2002, 360(9326) : 57 - 58.
  • 5HOTTA k, FUNAHASHI T, BODKIN N C, et al. Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys [J]. Diabetes, 2001,50(5): 1126 - 1133.
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  • 7Miyazaki T, Shimada K, Mokuno H, et al. Adipocyte derived plasma protein, adiponectin, is asiociated with smoking status in patients with coronary artery disease. Heart,2003,89: 663-664.
  • 8Fruebis J, Tsao TS, Javorschi S, et al.Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci USA,2001,98:2005-2010.
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  • 10Ouchi N, Kihara S, Arita Y, et al. Novel modulator for endothelial adhesion molecules adipocyte-derived plasma protein, adiponectin. Circulation,1999,100:2473-2476.

共引文献27

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实用医学杂志
2008年 第5期

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