口腔致病菌与动脉粥样硬化的研究进展

Research advance of oral pathogens and atherosclerosis

大量的研究表明口腔感染与动脉粥样硬化的发生和发展有关。其相关机制主要包括细菌直接侵入血管内皮,损害血管内皮细胞,引起C反应蛋白(CRP)升高,促进炎症细胞因子释放和表达,促进血小板聚集以及通过自身免疫反应和炎症反应影响血管壁来促进动脉粥样硬化的发生。本文就近年来该领域的研究现状作一综述。

The links between the oral infection and atherosclerosis have been well documented by current epidemiological data. Oral infection contributes to atherosclerosis directly and indirectly in some ways, which are including that oral pathogens invade the artery endothelial cells, damage the endothelial cells, increases the C- reactive protein level, up-regulate the inflammatory gene and inflammatory cytokine production, trigger platelet aggregation and affect the vessel wall via inflammatory and immune responses. This article reviews the current understanding about the relationship between oral pathogens and atherosclerosis.