低氧诱导因子-1α与口腔肿瘤治疗

Hypoxia inducible factor-1α and oral tumor therapy

低氧诱导因子-1α(HIF-1α)是细胞低氧适应与应答调节的关键因子,在机体许多生理及病理过程中起关键作用。HIF-1α对肿瘤生物学特性改变的调控成为近年来肿瘤研究的热点之一。研究证实HIF-1α在动物及人体许多肿瘤中过量表达,并通过调控其下游基因的表达影响肿瘤的生长、血管形成、凋亡及侵袭与转移等特性。近年来HIF-1α与头颈部肿瘤发生和发展关系及基于HIF-1α的治疗策略的研究取得了较大的进展。本文就HIF-1α在口腔肿瘤治疗中的研究进展作一综述。

Hypoxia inducible factor-1α（HIF-1α） is a key factor of cell hypoxia adaptation and response mediation and plays a pivotal role in many physiological and pathologic processes, such as inflammatory diseases and tumor. The study of HIF-1α controlling tumor biological characteristic changes becomes a present hotspot of tumor research. It has been shown that over expression of HIF-1α in many animal and human tumor influences on tumor growth, angiogenesis, apoptosis, invasion and metastasis properties through controlling its downstream genes. Recently, great achievements have been made in the relationship between HIF-1α and development of head and neck neoplasm based on HIF-1α therapy strategies. In this review, it was discussed relevant literatures on HIF-1α with research progress in oral tumor therapy.