香菇多糖注射液联合卡铂治疗恶性胸腔积液临床疗效观察

Clinical effect of combination of lentinan injection and carboplatin in patients with malignant pleural effusion

目的探讨香菇多糖注射液联合卡铂治疗恶性胸腔积液的临床疗效。方法63例恶性胸腔积液患者随机分为观察组和对照组，观察组采用香菇多糖注射液联合卡铂治疗，对照组单用卡铂。结果治疗后5周观察组总有效率（CR＋PR）为81．2％，对照组总有效率（CR＋PR）为61．3％，两组比较差异有统计学意义（P〈0．05）。观察组生存质量HPS评分提高率（54．8％）较对照组（39．1％）明显升高（P〈0．05）。结论香菇多糖注射液联合卡铂治疗恶性胸腔积液疗效优于单用卡铂。

Objective To evaluated the efficacy of lentinan injection and carboplatin for malignant pleural effusions. Methods 63 patients were divided into the experimental group and control group. The experimental group were adminstered lentinan injection and carboplatin. Results The response rate of the experimental group was 81.2 %, the control group was 61.3 %. The better quality of life appeared in the experimental group. Conclusion Postoperative lentinan injection and carboplatin in formalignant pleural effusions is a beneficial therapeusis that helps to improve survival rates and qulity of life.