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胰岛素肺吸入剂的研究现状与趋势 被引量:1

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摘要 目的综述胰岛素肺吸入剂的制剂、给药装置、药效学等方面的研究现状与趋势。方法查阅国内外有关的文献,并进行总结分析。结果与结论胰岛素的肺吸入剂为糖尿病患者提供了一种非侵入性的给药剂型,值得进一步研究。
出处 《中国药学杂志》 CAS CSCD 北大核心 2008年第5期324-326,335,共4页 Chinese Pharmaceutical Journal
基金 国家863专题课题资助(2007AA02Z171)
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参考文献26

  • 1BLISS M. The Discovery of Insulin [M]. Chicago : The University of Chicago Press, 1982:80.
  • 2蔡乐,朱珠.非注射途径胰岛素制剂的研究进展[J].中国药科大学学报,2007,38(2):105-107. 被引量:8
  • 3CEFALU W T, BINDRA S. Inhaled insulin : a novel route for insulin delivery [ J ]. Expert Opin Investig Drugs, 2002,11 ( 5 ) : 687- 691.
  • 4LENZER J. Inhaled insulin is approvd in Europe and United States[J]. BMJ,2006,332:321.
  • 5HARSCH I A. Inhaled insulins:their potential in the treatment of diabetes mellitus [J]. Treat Endoerinol,2005,4 : 131-138.
  • 6ANONYMOUS. Puhnonary medicine : Novo nordisk, aradigm start phase Ⅲ studies of AERx insulin delivery system [ J ]. Diabetes Week, 2002,15.
  • 7RUBSAMEN R M,LLOYD L. Method of administration of insulin:The United States,5672581 [ P]. 1997-09-30.
  • 8JOHN R W. Inhaled insulin: an overview [ J ]. Clin Diabetes, 2001,19 : 13-16.
  • 9DAVID A E, JUSTIN H. Large porous particles for puhnonary drug delivery[ J ]. Sciences, 1997,276 ( 20 ) : 1868 -1871.
  • 10ROSENSTOCK J,BAUGHMAN R A,RIVERA S T,et al. A randomized, double-blind, placebo controlled study of the efficacy and safety of inhaled Technophere insulin in patients with type 2 diabetes ( T2 DM) [ J ]. Diabetes,2005,54.

二级参考文献38

  • 1王强,刘新月,李乃适.临床常用胰岛素制剂的分类及特点[J].临床药物治疗杂志,2005,3(6):47-52. 被引量:21
  • 2王祥香,孙子林.糖尿病药物治疗新进展——来自2005年欧洲糖尿病年会的最新信息[J].中国药科大学学报,2006,37(2):105-110. 被引量:9
  • 3蔡乐,朱珠,王强,刘新月.胰岛素类似物与新型降糖激素类药物[J].中国新药杂志,2007,16(6):432-437. 被引量:26
  • 4Durra C, Curran MP. Inhaled human insulin ( Exubera ) : a review of its use in adult patients with diabetes mellitus. Drugs,2006, 66:1013-1032.
  • 5Patton JS, Bukar JG, Eldon MA. Clinical pharmacokinetics and pharmacodynamica of inhaled insulin. Clin Pharmacokinet, 2004,43 : 781-801.
  • 6Scholtz HE, Pretorius SG, Wessels DH, et al. Pharmacokinetic and glucodynamic variability: assessment of insulin glargine, NPH insulin and insulin ultralente in healthy volunteers using a euglycaemic clamp technique. Diabetologia, 2005,48 : 1988-1995.
  • 7Kapitza C, Hompesch M, Scharling B, et al. Intrasubject variability of inhaled insulin in type 1 diabetes: a comparison with subcutaneous insulin. Diabetes Technol Ther,2004, 6: 466-472.
  • 8Quattrin T, Belanger A, Bohannon NJV, et al. Efficacy and safety of inhaled insulin (Exubera) compared with subcutaneous insulin therapy in patients with type 1 diabetes, results of a 6-month,randomized, comparative trial. Diabetes Care,2004, 27:2622-2627.
  • 9Patton JS, Bukar JG, Eldon MA. Clinical pharmacokinetics and pharmacodynamics of inhaled insulin[ J ]. Clin Pharmacokinet, 2004,43(12) : 781 - 801.
  • 10Valente AX, Langer R, Stone HA, et al. Recent advances in the development of an inhaled insulin product[ J ]. Bio Drugs, 2003, 17( 1 ) : 9 - 17.

共引文献16

同被引文献15

  • 1王健松,朱家壁,吕瑞勤,沈伟.肺靶向阿奇霉素脂质体的制备及其在小鼠体内的分布[J].药学学报,2005,40(3):274-278. 被引量:30
  • 2曾敏捷,胡桂林,郑峰,樊建人.电厂排放烟气中的小颗粒在呼吸道内运动沉积的数值模拟[J].能源工程,2005,25(3):36-41. 被引量:6
  • 3黄玥,唐豪,杨事民,J.Y.Tu.基于CFD技术的鼻腔输药的流动特性研究[J].沈阳航空工业学院学报,2007,24(3):17-23. 被引量:4
  • 4Cheng YS, Zhou Y, Chen BT. Particle deposition in a cast of human oral airways [J].Aerosol Sci Technol, 1999, 31 (4) : 286-300.
  • 5Anderson JD Jr. Computational Fluid Dynamics: the Basics with Applications [M]. New York: McGraw-Hill, 2002: 4.
  • 6Martonen TB, Zhang Z, Yu G, et al. Three-dimensional computer modeling of the human upper respiratory tract[J]. Cell Biochem Biophys, 2001, 35 (3) : 255-261.
  • 7Stapleton KW, Guentsch E, Hoskinson MK, et al. On the suitability of K-ε turbulence modeling for aerosol deposition in the mouth and throat: a comparison with experiment [J]. JAerosol Sci, 2000, 31 (6) : 739-749.
  • 8Li Z, Kleinstreuer C, Zhang Z. Particle deposition in the human tracheobronchial airways due to transient inspiratory flow patterns[J]. JAerosol Sci, 2007, 38 (6) : 625-644.
  • 9Zhang Z, Kleinstreuer C, Kim CS. Micro-particle transport and deposition in a human oral airway model [J].JAerosol Sci, 2002, 33 (12): 1635-1652.
  • 10Martonen TB, Zhang Z, Yue G, et al. 3-D Particle transport within the human upper respiratory tract [J].JAerosol Sci, 2002, 33 (8) : 1095-1110.

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