电子细胞中的基因表达调控研究

Research on regulation of gene expression in E-Cell

基因表达调控决定了基因组中遗传信息表达为影响细胞生命活动的蛋白质组的数量、成分和功能,现有的电子细胞模型对基因表达调控模拟得较少。提出Analog-Cell电子细胞模型,通过定义反应过程中的调节因子和酶以及制定合理的反应规则,有效地模拟了基因表达中主要的调控机制,真实地再现了细胞内基因表达这一生命活动,并得到了比较理想的模拟结果。

The regulation of gene expression determines the quantity, structure and functions of proteome that are translated by the genetic information of genome and affect the life activities of cells. Existing electronic cell （E-Cell） models seldom relate to simulation on the regulations of gene expressions. In this paper, the E-Cell model named Analog-Cell was proposed. It simulated the main regulation mechanisms of gene expression through defining regulation factors, enzymes and rational reaction rules. Thus Analog-Cell realistically represents the procedure of gene expression and obtains recommendable simulation results.