盐酸伪麻黄碱在人体中的药物动力学

Pharmacokinetics of pseudoephedrine in human body by RP HPLC

采用反相高效液相色谱外标法测定人血清中伪麻黄碱浓度，并测定８例志愿受试者伪麻黄碱血药浓度，并计算分析药物动力学参数，结果单剂量口服９０ｍｇ盐酸伪麻黄碱后，药时曲线呈一室模型。Ｔｍａｘ＝１．７±１．１ｈ，Ｃｍａｘ＝３６４±９４ｎｇ·ｍｌ－１，ＡＵＣ（０～∞）＝２６６２±３０３（ｎｇ·ｈ·ｍｌ－１），Ｔ１／２＝４．０±１．０ｈ，Ｋａ＝２．４±１．４ｈ－１，Ｋｅ＝０．１９±０．０４ｈ－１，Ｖｄ＝０．１９±０．０５ｍｇ，Ｃｌ＝０．０３±０．０１ｍｇ·ｈ－１。

The serum concentration of pseudoephedrine was determined by RP HPLC method. The linear range was 50￣750ng·ml -1 . The recovery rate of high, middle, low concentration was 79 ± 4% , 80.7 ± 3.7% , 81.6 ± 1.4% ( n =5), respectively. Coefficients of inter day and intra day variations were less than 5.66% . The serum concentration of pseudoephedrine were determined in 8 volunteers. The pharmacokinetic parameters were calculated and analyzed. After a single oral dose of pseudoephedrine 90mg had been given to each volunteer, the pharmacokinetics of pseudoephedrine was shown by one compartment model. T max = 1.7 ± 1.1h , C max = 364 ± 94 ng·ml -1 , AUC 0-∞ = 2662 ± 303 (h·ng)·ml -1 , T 1/2 = 3.8 ± 1.0h , Ka = 2.4 ± 1.4 h -1 , Ke = 0.19 ± 0.04 h -1 , Vd = 0.19 ± 0.05mg , Cl = 0.03 ± 0.01 mg·h -1 .