呼吸系统感染患者口服头孢普齐的尿药动力学

The pharmacokinetic study of cefprozil in urianry

研究了１０例健康志愿者和１０例呼吸系统感染患者单次及多次口服５００ｍｇ头孢普齐后的尿中药物动力学特性。尿药浓度采用高效液相色谱法测定。单次口服５００ｍｇ头孢普齐后，健康组和患者组０～４８ｈ的尿中药物回收率分别为５９．３％和５７．２％，经ｔ检验两组间结果无显著性差异。在每天５００ｍｇ连续７ｄ的多次口服给药实验中，组间相比及单剂量与多剂量相比，药物动力学参数无显著性差异。

Pharmacokinetics of cefprozil was studied in 10 healthy volunteers and 10 patients with respiratory tract infections after a single dose and multiple dose of 500mg.The concentration of cefprozil in urine was measured by high performance liquid chromatography. In single dose studies, each of the volunteers and patients was given 500mg of cefprozil orally. The pharmacokinetic parameters obtained from the volunteers and patients respectively showed that urinary recovery rates within 0～48h were 59.3% and 57.2% , no singnificant difference between the two groups. With oral multiple dose of 500mg of cefprozil once over 7 consecutive days, the paramaters on day 1 and day 7 were significantly different. No obvious accumulation of the drug was noted in multiple dose administration.