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实时定量PCR检测Bcl-2/IgH融合基因在淋巴瘤中的应用

Application of Real-time Quantitative PCR Detecting Bcl-2/IgH Fusion Gene in Lymphoma
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摘要 Bcl-2/IgH融合基因是淋巴瘤的肿瘤特异性标志,见于85%～90%的滤泡性淋巴瘤及30%的弥漫性大B细胞淋巴瘤患者。大量研究表明,该融合基因与滤泡性淋巴瘤和弥漫性大B细胞淋巴瘤有很好的相关性,对Bcl-2/IgH的定量检测能反应淋巴瘤的临床进程。现就实时定量PCR技术对Bcl-2/IgH融合基因的检测在淋巴瘤的分期、疗效评价、预测复发和预后评估等方面的临床意义进行综述。 The Bcl-2/IgH fusion gene is the specific mark of malignant lymphoma.It was expressed in 85%~90% cases of follicular lymphoma（FL） and 30% diffuse large B-cell lymphoma（DLBCL）.Studies showed that this fusion gene has good correlativity with follicular lymphoma and diffuse large B-cell lymphoma,and the quantitative detection of this fusion gene can reflect the clinical process of lymphoma.This article reviews clinical significance of Bcl-2/IgH fusion gene detection by RQ-PCR in the staging,evaluation of curative effect,prediction of recurrence,and prognostic evaluation.
作者 徐明 张学美
机构地区 昆明医学院第一附属医院血液科
出处 《医学综述》 2008年第6期811-813,共3页 Medical Recapitulate
关键词 BCL-2/IGH 融合基因 淋巴瘤 实时定量聚合酶链反应 Bcl-2/IgH Fusion gene Lymphoma Real-Time Quantitative polymerase chain reaction
分类号 R733.4 [医药卫生—肿瘤] R730.43 [医药卫生—肿瘤]
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参考文献21

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医学综述
2008年 第6期

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