摘要
采用02g·L-1氨水喂养诱发大鼠萎缩性胃炎,定量观察不同剂量中药胃痛灵及丽珠得乐对萎缩性胃炎的治疗作用,结果表明:(1)中、小剂量胃痛灵能明显增加胃体粘膜表面上皮层厚度,从而改善胃粘膜屏障功能,其效果优于丽珠得乐;(2)各剂量胃痛灵能增加胃体粘膜PAS(+)层厚度,从而改善胃粘液屏障功能;(3)胃痛灵可明显抑制胃窦粘膜急性炎症反应从而减轻炎性损伤,尤以小剂量胃痛灵效果为佳。
Atrophic gastritis in rats was induced by using 0 2 g·L -1 ammonia solution administrated as drinking water. The therapeutic effects of medicinal herb Weitongling (WTL) at varied dosages and Lizhudele (DeNol) on atraphic gastritis were observed quantitatively. The results showed: (1) WTL at moderate and small dosages might obviously increase the thickness of superficial epithelium in the body mucosa to improve the function of gastric mucosal barrier. The effect of WTL was more significant than that of DeNol; (2) WTL at varied dosages might increase the PAS positive thickness in body mucosa to improve the function of gastric mucous barrier; (3) WTL, especially at small dosage, might markedly inhibit acute inflammatory reaction in the antral mucosa to decrease inflammatory damages.
出处
《安徽医科大学学报》
CAS
1997年第4期312-314,共3页
Acta Universitatis Medicinalis Anhui
关键词
萎缩性胃炎
中医药疗法
胃痛灵
MeSH gastritis, atrophic/drug ther
gastritis, atrophic/TCM ther
gastrointestinal agents rats Free words weitongling
lizhudele