埃兹蛋白和上皮型钙黏附素在食管鳞状细胞癌中的表达及其意义

Expression and significance of Ezrin and E-cadherin in esophageal squamous cell carcinoma

目的探讨埃兹蛋白(Ezrin)和上皮型钙黏附素(E-cadherin)在食管鳞状细胞癌(ESCC)中的表达及与临床病理因素之间的关系。方法应用免疫组化S-P法检测Ezrin和E-cadherin在45例ESCC组织和20例癌旁正常食管组织中的表达。结果Ezrin和E-cadherin在食管鳞癌中的异常表达率分别为71.11%和77.78%,Ezrin和E-cadherin的异常表达与食管鳞癌的浸润深度、分化程度、TNM分期和淋巴结转移显著相关(P<0.05)。Ezrin的表达升高和E-cadherin的表达缺失呈负相关(r=-0.997,P=0.048)。结论Ezrin和E-cadherin的异常表达与ESCC的进展和淋巴结转移有关,可作为预测肿瘤预后的指标。

Objective To investigate the expression of Ezrin and E - cadherin in esophageal squamous cell carcinoma （ESCC）and their relationship with the clinical and pathologic factors. Method Tissue specimens from 45 cases of ESCC and 20 cases of adjacent normal tissue were studied by S - P immunohistochemistry using monoclonal antibodies to Ezrin and E - cadherin. Results The rates of abnormal expresstion were 71.11% for Ezrin and 77.78% for E - cadherin in ESCC. The abnormal expresssion rates were highly related to the invasiveness, differentiation, TNM stages and lymphatic metastasis of the cancer. The high expression of Ezrin was negatively correlated with the low expression of E - cadherin（ r = - 0.997, P = 0.048 ）. Conclusion The abnormal expression of Ezrin and E - cadherin is closely associated with the development and metastasis of ESCC. Detection of Ezrin and E - cadherin proteins in ESCC might offer important prognostic information.