可生物降解聚天冬氨酸水凝胶的合成及性能

The Synthesis and Characteristics in Vitro of Biodegradable Poly(L-Aspartic Acid) Hydrogels

采用两步交联法合成了可生物降解聚天冬氨酸水凝胶。首先用赖氨酸作为内交联剂对聚丁二酰亚胺进行开环反应,以侧基的形式引入聚合物链中,然后用戊二醛为表面交联剂进行进一步交联反应,从而形成水凝胶。研究了反应温度、时间、赖氨酸及戊二醛用量对水凝胶溶胀性能的影响。并对水凝胶的溶胀机理进行了初步的探讨,结果表明,溶胀过程属于非Fickian扩散。pH敏感性测试表明水凝胶在pH=3.4时收缩,而在pH<3.4和pH>3.4时溶胀,且在中性和碱性条件下的溶胀率大于在酸性条件下的溶胀率。

Biodegradable poly （L-aspartic acid） hydrogels were synthesized by a two-step crosslinking reaction. L-lysine was first introduced into the polymer as the side chain by the ring-opening reaction, and the hydrogel was then prepared by the cross-linking reaction with glutaraldehyde. Effects of the reaction temperature and time, and amounts of cross-linking agents on the swelling behavior of the hydrogel were studied. The swelling mechanism was discussed. Results show that the swelling process is non-Fickian diffusion. At pH = 3.4, the hydrogel shrunk the most but swelled when pH〈3.4 and pH〉3.4. The swelling ratio （SR） of the hydrogel in alkaline solution is much larger than that in acidic solution.