2,5-二甲基-3,4-二乙酰基呋喃及其衍生物的合成

The Synthesis of 2,5-Dimethyl-3,4-Diacetylfuran and Its Derivatives

以ＫＩ－ＮａＩ为间接电解质，丙酮为溶剂，用间接电氧化的方法将乙酰丙酮（３）、乙酰乙酸乙酯（４）进行偶联反应，高产率地得到偶联产物四羰基化合物（５－６），进而在酸性介质中经Ｐａａｌ－Ｋｎｏｒｒ环化，合成了２，５－二甲基－３，４－二乙酰基呋喃（７）和２，５－二甲基－３，４－二乙氧羰基呋喃（８）。（７）再经ＮａＢＨ４还原得２，５－二甲基－３，４－二（１－羟基乙基）呋喃（９）。

This paper reported the synthesis of 2,5-dimethyl-3,4 diacetylfuran (7) and 2,5-dimethyl-3,4-diethoxycarbonyl (8),which is given in TsOH/benene-ethy1 acetate system through Paal-Knorr cyclization of the electroxidative coupling products of acetoacetone (3) and ethyl acetylacetate (4), respectively. Then, (7) was reduced by NaBH 4/CH 3OH, providing the reductive product 2,5-dimethyl-3,4-bi(1-hydroxyethy1)furan (9).