摘要
Lewis酸催化对甲氧乙基苯基缩水甘油醚与异丙胺的反应得到美托洛尔,考察不同的催化剂、反应温度、反应时间对反应的影响。结果表明:FeCl3对该反应有较好的催化性能,收率可达80%。
Metoprolol was synthesized with isopropylamine and 4-（2-methoxyethyl）phenyl glycidyl by different Lewis acid.Effect of different Lewis acid,reaction temperature,reaction time on the yield of Metoprolol were considered.Result showed that FeCl3 was an efficient catalyst for the synthesis of Metoprolol.The yield was 80%.
